Terpenoid synthases create diverse carbon skeletons by catalyzing complex carbocation rearrangements, making them particularly challenging for enzyme function prediction. To begin to address this challenge, we have developed a computational approach for the systematic enumeration of terpenoid carbocations. Application of this approach allows us to systematically define a nearly complete chemica...

This paper describes eight telephone-speech corpora at various stages of development at the Center for Spoken Language Understanding. For each corpus, we describe data collection procedures, methods of soliciting callers, protocol used to collect the data, transcriptions that accompany the speech data, and the expected release date. The corpora are available at no charge to academic institutions.

During the evolution of multicellular organisms, the unit of selection and adaptation, the individual, changes from the single cell to the multicellular group. To become individuals, groups must evolve a group life cycle in which groups reproduce other groups. Investigations into the origin of group reproduction have faced a chicken-and-egg problem: traits related to reproduction at the group l...

The availability and cycling of nutrients is determined by an interaction of physical, chemical, and biological processes in an ecosystem. This interaction of processes, collectively known as biogeochemistry, is important as it determines the forms, transformations, and ultimate fate of nutrients in a given system. This chapter focuses on biogeochemical processes in springs and spring runs with...

1. Larval-specific protein, LSP, reaches a peak concentration in cockroach hemolymph 2448 hr prior to ecdysis. 2. When ecdysis is delayed by autotomy-induced leg regeneration, LSP continues to accumulate and reaches a higher than normal peak concentration 28 hr prior to the delayed ecdysis. 3. Ecdysone inhibits the regeneration-induced delay and returns the normal pattern of ecdysis and LSP acc...

STUDY QUESTION What is the effect of natural cycle IVF in women with poor ovarian response according to the new ESHRE definition for poor ovarian responders: the Bologna criteria? SUMMARY ANSWER Although natural cycle IVF is a promising treatment option for normal responders, poor ovarian responders, as described by the Bologna criteria, have a very poor prognosis and do not appear to experie...

The objective of this study was to compare letrozole-stimulated cycles to natural cycles in 208 patients undergoing intrauterine insemination (IUI) between July of 2004 and January of 2007. Group I (n = 47) received cycle monitoring only (natural group), Group II (n = 125) received letrozole 2.5 mg/day on cycle days three to seven, and Group III (n = 36) received letrozole 5 mg/day on cycle day...

 liquefied natural gas (LNG) is the most economical way of transporting natural gas (NG) over long distances. Liquefaction of NG by using vapor compression refrigeration system requires high operating and capital cost. Due to lack of systematic design methods for multistage refrigeration cycles, the conventional approaches of determining optimal cycle configuration are mostly based on trial-an...