OBJECTIVE To delineate the histopathological characteristics of nasal mucosa in refractory chronic rhinosinusitis with nasal polyps (CRSwNP) in order to demonstrate subtypes of nasal polyps and their potential relation with lower airway comorbidity. STUDY DESIGN Clinical- and pathological-based cross-sectional study Methods: Nasal polyp specimens were prospectively collected from patients wit...

Neurofibromas are benign peripheral nerve sheath tumors which originate from Schwann cells. They are known to occur in extremities as a local manifestation of Von Recklinghausen’s disease i.e. type 1 neurofibromatosis, but isolated neurofibroma occurring in the nasal cavity is a rare entity. Here we report one such case in a 60 year old lady who, presented to us with complaints of difficulty in...

Nasal polyposis represents as a chronic hyperplastic sinusitis associated with chronic inflammation. In present retrospective study, we aimed to compare the Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Neutrophil to Lymphocyte Ratio (NLR) values of patients with nasal polyposis to those in healthy subjects. We included 35 nasal polyp patients and 45 healthy subjects into th...

Antrochoanal polyp is a benign polypoid lesion arising from the oedematous mucosa of the maxillary sinus and extending through the maxillary ostium into the nose. In children, it constitutes 33% of all nasal polyps. Surgery is the usual treatment for antrochoanal polyps. The primary aim of treatment for antrochoanal polyp is complete removal with total clearance of the maxillary sinus. Herein, ...

This study aimed to investigate the prevalence of human papilloma virus (HPV), herpes simplex virus-1/-2 (HSV-1/-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus-6/-7 (HHV-6/-7) in 23 human nasal polyps by applying PCR. Two types of control tissues were used: adjacent inferior/middle turbinates from the patients and inferior/middle turbin...

Rhinosporidiosisis a rare mycotic disease caused by Rhinosporidiumseeberithat affects both humans and animals. We report the case of 12-year-old girl who presented with six month history progressive right nasal obstruction ipsilateral epistaxis. Clinical examination revealed pedicled polyp on underside lower cornea nostril. Histological excised confirmed rhinosporidosis. Follow-up after 2 years...

Mesenchymal stromal cells (MSCs) are considered adult progenitor stem cells and have been studied in a multitude of tissues. In this context, the microenvironment of nasal polyp tissue has several inflammatory cells, but their stroma compartment remains little elucidated. Hence, we isolated MSCs from nasal polyps Polyp-MSCs (PO-MSCs) and compared their molecular features and gene expression pat...

BACKGROUND The cysteinyl leukotrienes (cysLTs) are proinflammatory lipid mediators that act on the type 1 cysLT receptor (CysLT1R) in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). GPR17, a G protein-coupled orphan receptor with homology to the cysLT receptors, has been proposed as a damage sensor during inflammation. However, the expression and correlation of GPR17 and ...

153 Effect of Simvastatin on Transforming Growth Factor BETA-1Induced Myofibroblast Differentiation and Collagen Production in Nasal Polyp-Derived Fibroblasts Il-Ho Park, MD, and Heung-man Lee, MD, PhD. Department of otorhinolaryngology-head and neck surgery, Korea university college of medicine, Seoul, South Korea. Background: Statins are the most commonly prescribed drugs for the treatment of...