PURPOSE Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loade...

Chitosans and pectins are natural polysaccharides which show great potential in drug delivery systems. Chitosans are a family of strongly polycationic derivatives of poly-N-acetyl-D-glucosamine. This positive charge is very important in chitosan drug delivery systems as it plays a very important role in mucoadhesion (adhesion to the mucosal surface). Other chitosan based drug delivery systems i...

Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic an...

Abstract AIMS Several techniques, such as intra-cerebrospinal fluid chemotherapy, ultrasound-mediated blood-brain barrier disruption, convection enhanced delivery, polymer delivery systems, electric field therapy, and intra-arterial intra-nasal have the potential to transform treatment of brain tumours in children. However, there been very few clinical trials evaluate these. We aim address chal...

Part 2 of this paper deals with the techniques for drug delivery of topical and injectable local anaesthetics. The various routes of local anaesthetic delivery (epidural, peripheral, wound catheters, intra-nasal, intra-vesical, intra-articular, intra-osseous) are explored. To enhance transdermal local anaesthetic permeation, additional methods to the use of an eutectic mixture of local anaesthe...

The aim of the present work was to formulate and evaluate betahistine-loaded chitosan microspheres intended for nasal delivery with focus on their mucoadhesive properties. Betahistine-loaded chitosan microspheres were obtained via W/O emulsion solvent evaporation technique and were characterized for particle size, surphace morfology and entrapment efficiency. FTIR spectroscopy was carried out t...

Most common methods of delivery include the preferred topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) inhalation routes. The conventional dosage forms provide drug release immediately it causes fluctuation level in blood depending upon form. Therefore to maintain concentration within therapeutically effective range needs novel system. In past few decades, co...

Aerogels are the lightest processed solid materials on Earth and with largest empty volume fraction in their structure. Composition versatility, modularity, feasibility of industrial scale manufacturing behind fast emergence aerogels drug delivery field. Compared to other 3D materials, high porosity (interconnected mesopores) specific surface area may allow faster loading small-molecule drugs, ...

Streptomycin, the foremost class of drugs called aminoglycosides to be discovered is the only antibiotic remedy for tuberculosis. Streptomycin cannot be given orally, but must be administered by regular intramuscular injections as it is reported to have unreliable absorption throughout the GIT. Further to this, its use in cerebral tuberculosis is minimal as it does not cross the blood brain bar...