cardiovascular effects of opioid withdrawal have long been studied. it was reported that patients with underlying ischemic heart disease and atherosclerotic vessels may be complicated by a sudden physical and emotional stress due to withdrawal syndrome. but some other believes sudden increase in catecholamine level as a sympathetic overflow might effect on heart with and without underlying isch...

Methods: Pregabalin utilization and its impact on concomitant medication use were assessed via a retrospective evaluation of 387 patients treated at Lahey Clinic Interventional Pain Management Center. Using an e-prescribing database, records were reviewed to assess utilization of pregabalin and concomitant medications for 3 months prior to and after the initiation of therapy. We assumed patient...

Narcotics misappropriations have the bad impacts for nation generation continuance. The anticipation needs cooperation from all society elements, such as family, every education stages until universities and government must be united on narcotic. Prevention efforts in environment around them. aims of this research are follows: 1. To find out steps which applied by low enforcement against narcot...

A 14-year-old female with suspected narcotic overdose had CYP2D6 genotyping performed to verify opiate intoxication. The role of pharmacogenetics in pain management and individualization of opiate pharmacotherapy is discussed.

In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%). Only nine infants required treatment. Sudden infant death syndrome occurred in two infants at 4 and 6 months.

A method is presented for developing sediment quality guidelines (SQG) for narcotic chemicals in general and polycyclic aromatic hydrocarbons (PAHs) in particular. The guidelines can be applied to any individual or mixture of narcotic chemicals including PAHs using only the chemical’s octanol/water partition coefficient. They are derived using the final chronic values for type I narcotics devel...

It has been know that, at a small dose, narcotic analgesics depress polysynaptic reflex activity in the spinal cats (1) and nociccptive reflexes in the spinal rats (2), as well as in spinal cats and dogs (3-6), where they do not depress, or slightly enhace the monosynaptic reflex (3). In order to explain this depression induced by narcotic analgesics, it has been suggested that the interneurons...