rats were treated with acetylsalicylic acid (150 mgikg b.w.per os daily) or naproxen (125 mg/kg b.w. per os daily) for six weeks. half of the rats received silymarin (17.5 mgikg b.w. per os daily) in the last three weeks of the experiment. it was found tliat administration of acetylsalicylic acid led to signs of hepatic damage (an increase in serum bilirubin level, alanine aminotransferase and ...

Rats were treated with acetylsalicylic acid (150 mgikg b.w.per os daily) or naproxen (125 mg/kg b.w. per os daily) for six weeks. Half of the rats received silymarin (17.5 mgikg b.w. per os daily) in the last three weeks of the experiment. It was found tliat administration of acetylsalicylic acid led to signs of hepatic damage (an increase in serum bilirubin level, alanine aminotransferase ...

Naproxen, a non-steroidal anti-inflammatory drug suggested for the long term treatment of disease conditions such as Rheumatoid Arthritis and Osteoarthritis poses an immediate risk of stomach ulceration. To avoid this risk, a proton pump inhibitor is often prescribed along with it. In the present study, Naproxen (500mg) is prepared in combination with Pantoprazole, a proton pump inhibitor as a ...

Migraine is a common multifactorial, neurovascular disorder, typically presenting as recurrent disabling attacks of headache, lasting for 4 to 72 hours, associated with nausea, photophobia, phonophobia and transient neurological aura symptoms. WHO recognizes migraine together with quadriplegia, dementia and psychosis as one of the most disabling disorders (1, 2). For the treatment of acute migr...

Three cases of digital vasculitis attributable to naproxen ingestion are reported. The vasculitic changes were reversed by withdrawal of the drug. These three cases emphasize the need to consider drug sensitivity as a cause of unexplained digital vascular lesions.

Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence...