Although solid lipid nanoparticles (SLNs) and nanostructured carriers (NLCs) have been successfully used as drug delivery systems for about 30 years, the usage of these food-grade nanovehicles nutraceuticals or bioactive compounds has been, relatively speaking, scarcely investigated. With fast-increasing interest in incorporation a wide range bioactives food formulations, well health awareness ...

Background: Apremilast (APR) is an orally administered selective phosphodiesterase 4 inhibitor approved to treat plaque psoriasis and psoriatic arthritis available as oral tablet formulation. However, its systemic side effects limit application. The low solubility permeability of apremilast make it difficult administer through the skin. Hence attempt made incorporate into a suitable nanocarrier...

Invasive mycoses are a major problem for immunocompromised individuals and patients in intensive care units. Morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. Moreover, the number of available antifungal agents is low, and there are problems with toxicity and resistance. Alternatives for treating invasive fungal infections are necessary....

The utilisation of lipid nanostructures that can in tandem act as Pickering emulsion stabilisers and active carrier/delivery systems, could potentially enable the development liquid (emulsion-based) formulations with capacity for multi-active encapsulation delivery. Part I this work focused on first aspect two-fold functionality by investigating both solid nanoparticles (SLNs) nanostructured ca...