Nanoparticles that are aimed at targeting cancer cells, but sparing healthy tissue provide an attractive platform of implementation for hyperthermia or as carriers of chemotherapeutics. According to the literature, diverse effects of nanoparticles relating to mammalian reproductive tissue are described. To address the impact of nanoparticles on cyto- and genotoxicity concerning the reproductive...

Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting ligands such as monoclonal antibodies, pep...

PURPOSE The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. METHODS Silica nanoparticles of two different sizes (20 nm and 100 nm) were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion ...

As a result of the development of nanotechnology in the last decade, silver nanoparticles emerged as an interesting alterative for the treatment of antimicrobial diseases and cancer, but its toxicological effects and its low biocompatibility were limiting its potential for clinical application [1-3]. The development of biosynthetic methods to obtain silver nanoparticles based on silver ions and...

Because of their unique physicochemical properties, engineered nanoparticles have the potential to significantly impact respiratory research and medicine by means of improving imaging capability and drug delivery, among other applications. These same properties, however, present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects...

Ovarian cancer is one of the leading causes of cancer death for women throughout the Western world. Kaempferol, a natural flavonoid, has shown promise in the chemoprevention of ovarian cancer. A common concern about using dietary supplements for chemoprevention is their bioavailability. Nanoparticles have shown promise in increasing the bioavailability of some chemicals. Here we developed five ...

Nanoparticles are being developed for diverse biomedical applications, but there is concern about their potential to promote inflammation, particularly in the lung. Although a variety of ambient, anthropogenic and man-made nanoparticles can promote lung inflammation, little is known about the long-term immunomodulatory effects of inert noninflammatory nanoparticles. We previously showed polysty...

objective(s):electromagnetic radiations which have lethal effects on the living cells are currently also considered as a disinfective physical agent.   materials and methods: in this investigation, silver nanoparticles were applied to enhance the lethal action of low powers (100 and 180 w) of 2450 mhz electromagnetic radiation especially against escherichia coli atcc 8739. silver nanoparticles ...

Over the last decade, the variety and number of products and techniques based on the use or the addition of engineered nanoparticles has increased dramatically. This includes among others the use of e.g. silver, titanium dioxide, or other nanoparticles in amultitude of personal care products, clothing, colors, and other consumer products (Schaumann et al., 2015-in this issue), and their direct ...

the application of nanotechnology in drug delivery and a variety of supplements is very impressive. in this regard, the use of this knowledge can be effective in the performance of medicinal plants in aquaculture. in the present study aloe vera was extracted and its nanoparticles were produced. three levels of aloe vera nanoparticles in siberian sturgeon (acipenser baerii) were evaluated for th...