objective(s): researchers have intended to reformulate drugs so that they may be more safely used in human body. polymer science and nanotechnology have great roles in this field. the aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted ph-responsive polymer.  methods: fe3o4 na...

The ultrasound-induced cleavage of covalent and non-covalent bonds to activate drugs (sonopharmacology) is a promising concept gain control over the action active pharmaceutical ingredients by an external trigger. Previously, linear polymer architectures bearing drug payloads were exploited for release using principles mechanochemistry. In this work, carrier design altered topology improve ultr...

Several tissue specific non-viral carriers have been developed for gene delivery purposes. However, the inability to escape endosomes, undermines the efficacy of these carriers. Researchers inspired by HIV and influenza virus, have randomly used Gp41 and H5WYG fusogenic peptides in several gene delivery systems without any rational preference. Here for the first time, we have genetically engine...

Abstract: The role of Proniosomes in oral controlled drug delivery system is well accepted. Presently, an attempt was made to develop cephradine (CP) prolong its duration action with better efficacy. Overall, eighteen formulation trials were developed using variable quantities sorbitol (F0S-F8S) and maltodextrin (F0M-F8M) carriers along span60 cholesterol. Trials evaluated for powder flowabilit...