We recently observed that the decanoylation of N-phenylthiocarbamoyl chitosan (2) with a mixture of decanoic anhydride and pyridine at 60 °C for 24 h afforded N,N-(decanoyl)phenythiocarbamoyl-/2-isothiocynato chitosan decanoate (3b) rather than the expected product N,N-(decanoyl)phenylthiocarbamoyl chitosan decanoate (3a). This result suggested that some of the N,N-(decanoyl)phenylthiocarmbamoy...

Background: Androgenic, Wnt and Notch pathways regulate progenitor development through unknown mechanisms. Results: Upregulation of Numb was blocked by Wnt inhibitors and required -catenin. Nandrolone promoted binding of ß-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensussites. Conclusion: Wnt/-catenin signaling mediates nandrolone-induced Numb...

Background: Anabolic-androgenic steroids are used at high doses by athletes for improving athletic ability, physical appearance and muscle mass. Therefore, the abuse of these steroids has been significantly increased. Many undesirable side effects of these steroids on the male reproductive function have been reported, however, little is known about their effects on sexual behavior and tissues o...

The phytochemical study of Dorstenia arifolia Lam. (Moraceae) has led to the identification of 18 triterpenes esterified by fatty acids, five triterpenes without esterification, 12 triterpenes esterified by acetic acid, together with a known furanocoumarin: α-amyrin (1), β-amyrin (2) α-amyrin acetate (3) β-amyrin acetate (4), α-amyrin octanoate (5), β-amyrin octanoate (6), α-amyrin decanoate (7...

We evaluated the effects of swimming and anabolic steroids (AS) on ventricular function, collagen synthesis, and the local renin-angiotensin system in rats. Male Wistar rats were randomized into control (C), steroid (S; nandrolone decanoate; 5 mg/kg sc, 2x/wk), steroid + losartan (SL; 20 mg.kg(-1).day(-1)), trained (T), trained + steroid (T+S), and trained + steroid + losartan (T+SL; n = 14/gro...

A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11 patients with and 17 patients without tardive dyskinesia. The results do not ...

The present study reports results pertaining to an "open trial" with long acting haloperidol decanoate injections in the maintenance therapy of schizophrenic patients satisfying DSM-III criteria. 33 patients suffering from schizophrenia entered the trial and were put or long acting haloperidol decanoate injections. The follow-up period was 6 months and the condition of the patients was monitore...