if lives were saved on only 10% of these occasions, then each would have been saved at a drug cost of £330-670. The range of doses given raises the possibility that naloxone was being titrated to effect resuscitation without provoking withdrawal. If so, recovery needs monitoring to avoid subsequent relapse into overdose. Some casualty departments and ambulance services now recommend giving nalo...

An acutely acquired dependence was investigated in rat hippocampal slices after brief exposure to morphine. Morphine augmented the population spike amplitude. Naloxone not only reversed the augmentation but decreased the amplitude to a level below that of the control. The inhibitory effect of naloxone correlated with the period of preincubation with morphine. These results suggested that the de...

In October 2002, the U.S. Food and Drug Administration approved buprenorphine-naloxone (Suboxone) sublingual tablets as an opioid dependence treatment available for use outside traditionally licensed opioid treatment programs. The NIDA Center for Clinical Trials Network (CTN) sponsored two clinical trials assessing buprenorphine-naloxone for short-term opioid detoxification. These trials provid...

BACKGROUND The aim of this study was to explore how changes in the expression of BDNF in MLDS change the effect of BDNF on dopamine (DA) neurons, which may have therapeutic implications for heroin addiction. MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other releva...

There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of morphine dependence. In this study, the effects of acute and chronic administration of nitrendipine on naloxone precipitated morphine withdrawal signs were investigated. Mice were rendered dependent to morphine by subcutaneous injection of morphine over a period of 5 days. In chronic s...

conclusions the results of the present study revealed that the aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats . results the results of the present study showed that agitation, disparity, and floppy eyelids in group e were significantly higher than those of others groups; however, these symptoms in group c were significantly lower ...

relieving withdrawal and post-abstinence syndrome of alcoholism is one of the major strategies in the treatment of alcohol addicted patients. diazepam, chlordiazepoxide, and topiramate are the approved medications that were used for this object. to assess the role of non-pharmacologic therapy in the management of alcohol withdrawal syndrome, we analyzed effects of forced exercise by treadmill o...

introduction: methadone has been used as a drug to detoxify opioid tolerance. naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. on the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking...

Objective: Opioid dependence is a chronic and complex disorder characterized by relapse remission. Chronic administration of morphine causes symptoms physical psychological dependence. The purpose the present study was to investigate effect anti-addictive drugs such as bupropion varenicline on naloxone precipitated withdrawal syndrome in rat model. Materials Methods: To assess morphine, Wistar ...