34 Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and 35 arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO, 36 ameliorates age-related vascular endothelial dysfunction and arterial stiffness in mice, but 37 effects on humans, including the metabolic pathways altered, are unknown. The purpose of this 38 study...
