Background—Cardiovascular risk estimation by novel biomarkers needs assessment in disease-free population cohorts, followed up for incident cardiovascular events, assaying the serum and plasma archived at baseline. We report results from 2 cohorts in such a continuing study. Methods and Results—Thirty novel biomarkers from different pathophysiological pathways were evaluated in 7915 men and wom...

Plasma brain natriuretic peptide (BNP), released from myocytes of ventricles upon stretch, has been reported to differentiate pulmonary from cardiac dyspnoea. Limited data have shown elevated plasma BNP levels in acute pulmonary embolism (APE), frequently accompanied by dyspnoea and right ventricular (RV) dysfunction. The aim of this study was to assess plasma N-terminal proBNP (NT-proBNP) in A...

We have isolated a cardiac natriuretic peptide of 5,000 d from atrial tissues from 500 rats and determined its amino acid sequence. The 5,000 d atrial natriuretic factor was elucidated to be a 45 amino acid peptide with the sequence of S-Q-D-S-A-F-R-I-Q-E-R-L-R-N-S-K-M- A-H-S-S-S-C-F-G-Q-K-I-D-R-I-G-A-V-S-R-L-G-C-D-G-L-R-L-F by sequencing the native peptide and its lysyl endopeptidase digests. ...

Among the comorbid conditions that significantly worsen quality of life and expectancy are chronic obstructive pulmonary disease heart failure. Difficulties drug therapy mutually exclusive approaches in treatment concomitant cardiovascular pathology. Aim this study was to provide scientific evidence possible use combined LCZ696 (angiotensin receptor neprilysin inhibitor, ARNI), which contains i...

Objective: To evaluate the efficacy and safety of Shenfu injection in treatment septic cardiomyopathy. Methods: Literatures on for sepsis published from establishment each database to December 31, 2020, were searched by computer; Cochrane risk-of-bias tool was used evaluating quality literatures, Review Manager 5.4 software meta-analysis. Results: Twenty random controlled trials (RCTs) included...

b-type natriuretic peptide (bnp) level is known to increase in patients with rheumatic mitral stenosis. in this systematic review, we aimed to discuss the possible association between plasma bnp level and the success rate of percutaneous transvenous mitral commissurotomy. pubmed and scopus databases were searched systematically, using the following key terms: “b-type natriuretic peptide” or “bn...