This paper introduces a lab project developed for the Summer Teachers’ Workshop in Genomics at Amherst College, and is easily tailored to the weekly format of undergraduate laboratory courses in genetics, genomics, molecular biology, or evolution. The project examines single nucleotide polymorphisms associated with human taste sensitivity to the bitter compound phenylthiocarbamide (PTC). Human ...

The human TAS2R38 receptor is believed to be partly responsible for the ability to taste phenylthiocarbamide (PTC), a bitter compound very similar to the bitter glucosinolates found in brassica vegetables. These vegetables and their active compounds have chemo-protective properties. This study investigated the relationship between genetic variation in the hTAS2R38 receptor and the actual consum...

The cytotoxic activities of three new synthetic catechol analogues, /H(p-hydroxyphenyl)amino|alanine (Compound 1), W-^-hydroxyphenyl)ornithine (Compound 2), and A^-i/n-hydroxyphenylJornithine (Compound 3), were determined against 10 human melanoma and 5 nonmelanoma cell lines. Activities of L-DOPA and 3,4-dihydroxybenzylamine were also measured. Dose-response curves were obtained and concentrat...

Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38) by means of structural bioinformatics and molecular d...

Let $R$ be a commutative ring with identity. A proper submodule $N$ of an $R$-module $M$ is an n-submodule if $rmin N~(rin R, min M)$ with $rnotinsqrt{Ann_R(M)}$, then $min N$. A number of results concerning n-submodules are given. For example, we give other characterizations of n-submodules. Also various properties of n-submodules are considered.

We observe some new characterizations of $n$-presented modules. Using the concepts of $(n,0)$-injectivity and $(n,0)$-flatness of modules, we also present some characterizations of right $n$-coherent rings, right $n$-hereditary rings, and right $n$-regular rings.