Huang, Qin-Heng, Victor J. Hruby, and Jeffrey B. Tatro. Role of central melanocortins in endotoxin-induced anorexia. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R864–R871, 1999.—Inflammation and microbial infection produce symptoms, including fever, anorexia, and hypoactivity, that are thought to be mediated by endogenous proinflammatory cytokines. Melanocortins are known to...

Stricklett, Peter K., Raoul D. Nelson, and Donald E. Kohan. The Cre/loxP system and gene targeting in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F651–F657, 1999.—The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby ...

Ikezaki, Hiroyuki, Manisha Patel, Hayat Önyüksel, Syed R. Akhter, Xiao-pei Gao, and Israel Rubinstein. Exogenous calmodulin potentiates vasodilation elicited by phospholipid-associated VIP in vivo. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1359–R1365, 1999.—The purpose of this study was to determine whether exogenous calmodulin potentiates vasoactive intestinal peptide (V...

Tian, Jean Q., and Andrea Quaroni. Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation. Am. J. Physiol. 276 (Cell Physiol. 45): C1245– C1258, 1999.—Using the conditionally immortalized human cell line tsFHI, we have investigated the role of cyclindependent kinase inhibitors (CKIs) in intestinal epithelial cell differentiation. Expression of cyclins, cyclin-...

Dobrian, Anca, Suzanne S. Wade, and Russell L. Prewitt. PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H2159–H2167, 1999.—We previously demonstrated remodeling of large and small arteries in angiotensin II-treated rats, paralleled by an increased expression of platelet-derived growth factor (PDGF)...

Meng, Xianzhong, Brian D. Shames, Edward J. Pulido, Daniel R. Meldrum, Lihua Ao, Kyung S. Joo, Alden H. Harken, and Anirban Banerjee. Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1525–R1533, 1999.—This study tested the hypothesis that in vivo norepinephrine (NE) treatme...

Taylor, Ryan P., M. Brennan Harris, and Joseph W. Starnes. Acute exercise can improve cardioprotection without increasing heat shock protein content. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1098–H1102, 1999.—The aim of this study was to determine the effects of acute bouts of exercise on myocardial recovery after ischemia and heat shock protein expression. Adult female Sprague-Dawley ra...

Together with other Bristolians, most of whom are now out of uniform, I have been asked to record a few of my personal experiences while in the Army. Where should one begin ? The events of the last few years seem already far away. Like so many, I joined the forces and saw something of the world. Never have so many travelled so much and often, apparently, so much at random. Events crowd each oth...

trauma, degenerative changes, infection, and autoimmune disorders such as rheumatoid arthritis and ankylosing spondylitis. The perception and resultant reporting of this pain vary significantly according to cultural and social circumstances. Honeyman and Jacobs noted that Australian Aborigines significantly underreport pain and are rarely disabled by pain. Social circumstances also play an impo...

O’Connor, Timothy P., and Jared Diamond. Ontogeny of intestinal safety factors: lactase capacities and lactose loads. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R753–R765, 1999.—We measured intestinal safety factors (ratio of a physiological capacity to the load on it) for lactose digestion in developing rat pups. Specifically, we assessed the quantitative relationships bet...