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P eskind et al (page 936) show that cerebrospinal fluid -amyloid 42 (A 42) but not A 40 decreased significantlywithage(Figure).Theage-associated decrease in cerebrospinal fluid A 42 was significantly and substantially greater in subjects with the apolipoprotein E*4 allele. These findings do have implications for the preclinical diagnosis of Alzheimer disease as well as for treatment.Theseobserv...
The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits. Remarkably, the cyclic neuroendocrine peptide somatostatin-1...
.......•. ..•.... .. .... .......... ..... ............ iv LIST OF FIGURES. . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi CHAPTER I .................................................. 1 Thesis Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Statistical Mechanics. . . . . . . . . . . . . . . . . . . . . . . ....
Among the family of Aβ peptides, pyroglutamate-modified Aβ (AβpE) peptides are particularly associated with cytotoxicity in Alzheimer's disease (AD). They represent the dominant fraction of Aβ oligomers in the brains of AD patients, but their accumulation in the brains of elderly individuals with normal cognition is significantly lower. Accumulation of AβpE plaques precedes the formation of pla...
We establish two results in the pointwise convergence problem of a trigonometric series [An] £ cne inl with lim Hm £ I bTck | = 0 |n|< -x. * Jn-»oo \k\-n for some nonnegative integer m. These results not only generalize Hardy's theorem, the Jordan test theorem and Fatou's theorem, but also complement the results on pointwise convergence of those Fourier series associated with known 1}-convergen...
Deer are considered important intermediate hosts for the coccidian parasites, Toxoplasma gondii and Neospora caninum. Antibodies to N. caninum and T. gondii were determined in sera of 42 mule deer (Odocoileus hemionus hemionus) and 43 black-tailed deer (Odocoileus hemionus columbianus) from Washington state, USA, using direct agglutination test with specific antigens. A titer of 1:25 was consid...
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