The poly-N-acetyllactosamines on neutrophils and monocytes have been shown to serve as ligands for various selectins present on endothelial cells and platelets. We have previously shown that only a limited number of glycoproteins contain poly-N-acetyllactosamine and found that lysosomal membrane glycoproteins (lamps) are the major glycoproteins carrying poly-N-acetyllactosamine. In order to und...

Single-site glycomuteins of recombinant human erythropoietin (rhuEpo) were constructed and transiently and stably expressed in BHK-21 cells. The transient expression levels varied among muteins, being highest for mutein rhuEpoGln24 followed by wild-type rhuEpo (rhuEpowt). All other glycomuteins, including rhuEpoGln38, rhuEpoGln83, rhuEpoThr126, and rhuEpoGly126, were secreted at lower levels th...

Renal carcinoid tumors are exceedingly rare tumors that have been primarily documented as case reports in the literature. In this study, we report a series of 21 renal carcinoid tumors, with emphasis on histopathologic features and clinical outcomes. Patient age ranged from 27 to 78 years (average 52 y). The majority of specimens consisted of radical nephrectomies with or without associated lym...

 Let $R$ be a ring‎, ‎and let $n‎, ‎d$ be non-negative integers‎. ‎A right $R$-module $M$ is called $(n‎, ‎d)$-projective if $Ext^{d+1}_R(M‎, ‎A)=0$ for every $n$-copresented right $R$-module $A$‎. ‎$R$ is called right $n$-cocoherent if every $n$-copresented right $R$-module is $(n+1)$-coprese-nted‎, ‎it is called a right co-$(n,d)$-ring if every right $R$-module is $(n‎, ‎d)$-projective‎. ‎$R$...

This survey was conducted at Howard University (HU) College of Pharmacy as part a Drug Information course, in which First-Year students learn how to perform literature search on pharmacy topic and run survey. A total 42 student respondents participated the Nearly 64% (n=27) wrongly thought that cimetidine reduces risk colon cancer, while 57.1% (n=24) gave wrong response that, even though is FDA...

Synthesis of monoterpene indole alkaloids, leuconoxine, leuconodine B, and rhazinilam, by transformation melodinine E via 6-hydro-21-dehydroxyleuconolam was established. The pivotal intermediate, 6-hydro-21-dehydroxyleuconolam, prepared from a ring-opening N,S-acetal formation the diaza[5.5.6.6]fenestrane skeleton subsequent chemoselective reduction. These results demonstrate that 6-hydro-21-de...

It has been shown that for distinct odd primes p1, p2, . . . , pn and q, all Moufang loops of order p1p2 · · · pnq are groups if and only if q is not congruent to 1 modulo pi for each i. In this paper, we extend that result to include Moufang loops of order p1p 2 2 · · · pnq. Mathematics Subject Classification: 20N05

The macrobicyclic title compound, C(23)H(35)N(3)O(8)S, contains two tertiary amide bridgehead N atoms and a toluene-sulfonamide N atom in the center of the five-atom bridging strand. The mol-ecule has a central cavity that is defined by the 18-membered ring identified by the N(2)O(4) donor atom set and two 15-membered rings with N(3)O(2) donor atom sets. The toluene-sulfonamide N atom adopts an...

Fluorescent in situ hybridization (FISH) with a 21q11-specific probe (CB21c1) consisting of three non-overlapping cosmids has been applied to interphase amniocytes of pregnancies at increased risk for fetal aneuploidy (N = 78) and to interphase lymphocytes, cultured and uncultured, of patients referred for Down syndrome (N = 19 and 28, respectively). In the uncultured amniocytes, six chromosome...

We present broadband imaging polarimetry of DR21 at 2.2µm. Background stars shining through the lobes of the bipolar outflow show polarization aligned with the long axis of the outflow, indicating a magnetic field geometry oriented along the flow axis. There is no indication of a spiral or turbulent magnetic field geometry in the lobes. The polarization of stars in the central cluster has a dif...