Background Excessive accumulation of amyloid β-protein (Aβ) is one the primary mechanisms that leads to neuronal death with phosphorylated tau in pathogenesis Alzheimer’s disease (AD). Protofibrils, high-molecular-weight Aβ oligomers (HMW-Aβo), are implicated be important targets modifying therapy AD. We previously reported phenolic compounds such as myricetin inhibit Aβ1-40, Aβ1-42, and α-synu...

Myricetin (Myr) is a f lavonoid that exerts anti-arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of Myr on Kv1.5 channels in HEK293 cells. The current of Kv1.5 channels (Ikur) in HEK293 cells was recorded using the whole-cell patch-clamp technique and the expression of the Kv1.5 protein was mea...

Abstract: Cloves contain many chemical compounds that can be used for health. COVID-19 is a disease shaking the world today. Many people feel impact of this disease. Until now, there no definite cure and vaccine handling COVID-19. Objective to determine interaction between in cloves (eugenol myricetin) main protease (6LU7). This study use molecular docking, method using 4 applications: autodock...

Flavonoids, a group of polyphenolic natural compounds, represent an important source of antioxidants in the human diet [ 1,2]. Although the mechanism of action of flavonoids is not well understood, these compounds have been found to be inversely related to mortality from coronary heart disease[3]. Aggregation of platelet is fundamental to a wide range of physiological processes, i.e. in the eve...

Prostat kanseri dünyada erkekler arasında en sık görülen ikinci kanser türüdür. kanserinin morbidite ve mortalitesi son zamanlarda artmıştır. Tedavisi için birçok alternatif yaklaşımlar geliştirilmeye çalışılsa da, prostat hala kötü prognoz sergilemekte yüksek ölüm oranları ile karşılaşılmaktadır. Myricetin, antikanser özelliği ilgi çeken doğal bir flavonoid bileşiktir. Yapılan in vitro vivo ça...

Label claims of vitamin E succinate and polyphenolic nutraceuticals are assessed. A validated HPLC method was utilized to assess vitamin E succinate products. Three novel LC/MS methods were used to assess the polyphenols, pterostilbene, phloretin, and myricetin, in dietary supplements. The amount of vitamin E succinate varied from 0-130% of the stated label content with two products containing ...