BACKGROUND Myocardial capillary perfusion is a prerequisite of myocellular viability after reperfusion of acute myocardial infarction. It was hypothesised that the magnitude of myocardial capillary perfusion, assessed by transmural signal intensity in venous contrast echocardiography as a corollary of the blood volume of myocardial capillaries, and the amount of viable myocardium, represented b...

BACKGROUND Inflammation and myocardial necrosis play important roles in ischemia/reperfusion injury after coronary artery occlusion and recanalization. The detection of inflammatory activity and the extent of myocardial necrosis itself are of great clinical and prognostic interest. We developed a dual, noninvasive imaging approach using molecular magnetic resonance imaging in an in vivo mouse m...

We aimed to evaluate the effect of melatonin on myo-cardial cell oncosis in the myocardial ischemia/reperfusion injury rat, and the role of the mitochondrial permeability transition pore (MPTP) therein. Sprague Dawley rats (N = 60) were randomly divided into five groups of 12 rats each: control, ischemia/reperfusion (I/R), melatonin treatment (MT), melatonin treatment + atractyloside (MT+ATR), ...

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) the treatment of choice is timely reperfusion by primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can in itself independently induce myocardial injury and cardiomyocyte death—a phenomen...

PURPOSE Melatonin, the most potent scavenger of toxic free radicals, has been found to be effective in protecting against pathological states due to the release of reactive oxygen species. This study was performed to establish the effect of high dose melatonin on protection against ischemia- reperfusion (I/R) injury in rat hearts. MATERIALS AND METHODS Forty male Sprague-Dawley rats were used...

Contemporary mechanical reperfusion therapy for acute myocardial infarction is aimed at early and complete restoration of myocardial perfusion. However, successful restoration of epicardial blood flow does not guarantee restoration of flow at the myocardial tissue level. The incidence of inadequate myocardial reperfusion after primary percutaneous coronary intervention (PCI) varies from 15-70%,...

The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The result...

OBJECTIVE Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute myocardial injury after ischemia-reperfusion remains unknown. To investigate the role of MMP-9 in myocardial infarction, we utilized a MMP-9 knockout mouse. METHODS AND RESULTS Standard homologous recombination in embryonic stem...

To investigate the possibility of predicting the occurrence of spontaneous coronary reperfusion in acute myocardial infarction we studied 91 patients in a randomized trial on the clinical efficacy of intracoronary streptokinase compared to conventional treatment. Of the 46 patients treated conventionally 40 had catheterization 6 weeks after the infarction. Spontaneous coronary reperfusion was f...

global myocardial ischemia and ischemia-reperfusion injury are potential adverse events related with cardioplegic arrest. beating heart surgery has avoided such complications and adapted to valve surgery following successful results published on myocardial revascularization. difficulty in weaning from cardiopulmonary bypass may be lessened by using on-pump beating heart surgery for mitral valve...