نتایج جستجو برای: myeloproliferative neoplasm

تعداد نتایج: 188264  

Journal: :Blood 2010
Juan Li Dominik Spensberger Jong Sook Ahn Shubha Anand Philip A Beer Cedric Ghevaert Edwin Chen Ariel Forrai Linda M Scott Rita Ferreira Peter J Campbell Steve P Watson Pentao Liu Wendy N Erber Brian J P Huntly Katrin Ottersbach Anthony R Green

The JAK2 V617F mutation is found in most patients with a myeloproliferative neoplasm and is sufficient to produce a myeloproliferative phenotype in murine retroviral transplantation or transgenic models. However, several lines of evidence suggest that disease phenotype is influenced by the level of mutant JAK2 signaling, and we have therefore generated a conditional knock-in mouse in which a hu...

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