Abstract Background Inflammation and oxidative stress are thought to play an important role in the pathophysiology of HFpEF through development endothelial dysfunction. Myeloperoxidase (MPO), a leukocyte-derived enzyme, functions as link between inflammation is interesting therapeutic target. Purpose To compare MPO levels old controls define clinical characteristics associated with high MPO. Me...

BACKGROUND AND PURPOSE Neutrophils are critically involved with ischemia and reperfusion injury in many tissues but have not been studied under conditions of reperfusion after focal cerebral ischemia. The present studies were conducted to confirm our previous observations quantifying neutrophils in rat permanent focal stroke using a myeloperoxidase activity assay and to extend them to transient...

Renal involvement especially glomerulonephropathy in polymyositis or dermatomyositis is considered rare. Crescentic glomerulonephritis is even more so. Herein, we report a patient who was diagnosed with concurrent polymyositis and myeloperoxidase-related crescentic glomerulonephritis. We discuss the association between polymyositis or dermatomyositis and renal involvement, glomerulonephropathy,...

Background: Oxidation of apolipoprotein A-I by myeloperoxidase has been proposed to deprive HDL of its cardioprotective effects. Result: Tyrosine 192 is the major site of chlorination in apoA-I in both plasma and lesion HDL isolated from humans. Conclusion: Chlorination of apolipoprotein A-I by myeloperoxidase generates a dysfunctional form of HDL in vivo. Significance: Quantifying apolipoprote...

Objective: The protective effect of silymarin (SMN) on mycophenolate mofetil (MMF)–induced duodenal disorders was investigated. Materials and Methods: Forty-two Wistar rats were assigned to seven groups including control and test groups. The control animals received saline and the test animals were treated with MMF (30 mg/kg, orally) and saline, MMF and SMN (25, 50, and 100 mg/kg, orally), MMF ...

Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins (histone, protamine) also exhibited cytotoxic activity. Myeloperoxidase isolated from human leuk...

Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmon...