Intestinal trefoil factor 3 (TFF3) plays an important role in repairing the intestinal mucosa. However, detailed mechanism regarding immune regulation by TFF3 is not well defined. Here, we reported that treatment of mouse BM cells and human peripheral blood mononuclear from healthy volunteers with activated polymorphnuclear myeloid-derived suppressor (PMN-MDSCs) vitro. We also found prostagland...

Our current understanding of human tumor-resident myeloid cells is, for the most part, based on a large body of work in murine models or studies enumerating myeloid cells in patient tumor samples using immunohistochemistry (IHC). This has led to the establishment of the theory that, by and large, tumor-resident myeloid cells are either "protumor" M2 macrophages or myeloid-derived suppressor cel...

Acute myeloid leukemia (AML) is regarded as a stem cell disease. However, no one unique marker expressed on cells (LSC) but not leukemic blasts nor normal hematopoietic (HSC). CD34+ CD38- with or without CD123 CD44 subpopulations are immunophenotypically defined putative LSC fractions in AML. Nevertheless, markers that can be effectively and simply held responsible for the intrinsical heterogen...

Abstract Myeloid-derived suppressor cells (MDSCs) are heterogeneous myeloid cell populations with immunosuppressive capacity, which contribute to immune regulation and tolerance induction. We previously reported impaired MDSC function in patients primary Sjögren’s syndrome (pSS) mice experimental SS (ESS). In this study, we first found that aryl hydrocarbon receptor (AhR) was highly expressed b...

Abstract INTRODUCTION Gliomas are the most prevalent type of brain tumors in adolescent and young adult population (AYA) one leading causes cancer- related death. Two-third glioma AYA patients affected by low-grade gliomas (LGGs), but yet there no specific treatments. Therefore, a significant percentage LGG experience tumor recurrence malignant progression to high-grade (HGG) immune microenviro...