نتایج جستجو برای: myeloablative
تعداد نتایج: 1963 فیلتر نتایج به سال:
Stimulated by the economic constraints in developing countries, we have been interested in changes in the therapeutic approaches to hematologic malignancies that may result in both simplification and reduction of costs.1-4 One of the changes that has been shown to result in diminished costs of the modern effective therapeutic regimens is the completion of the procedures on an outpatient basis. ...
The use of hematopoietic cell transplantation has expanded and evolved substantially in the last decade. New stem cell sources and stem cell mobilizing agents have been introduced in clinical practice. The incidence of life-threatening complications following autologous stem cell transplant procedures has decreased dramatically. Understanding the immune mediated effect of allogeneic stem cell t...
This review addresses pitfalls of clinical trials to evaluate new approaches for prevention or treatment of graft-versus-host disease. Determination of end points poses a difficult challenge in the design of clinical trials, and examples from previous studies are used to illustrate some of the pitfalls. Also discussed is the need for a new conceptual approach for evaluation of graft-versus-host...
We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was...
OBJECTIVES Successful treatment of severe, refractory Pemphigus vulgaris (PV) is reported. METHODS Reduced intensity, non-myeloablative conditioning was employed, followed by allogeneic hematopoietic stem cell transplantation (HSCT) from a fully matched sibling. RESULTS Treatment of refractory PV with myeloablation and subsequent allogenic HSCT has been previously reported, and sustained re...
Allogeneic stem cell transplantation remains the only curative therapy for myelofibrosis. Despite advances in transplant, the morbidity and the mortality of the procedure necessitate careful patient selection. In this manuscript, we describe the new prognostic scoring system to help select appropriate patients for transplant and less aggressive therapies. We explore the advances in non-transpla...
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) in children is one of the highest-risk ALL groups. Improved outcome in combination with imatinib has been reported. However, intensive chemotherapy or myeloablative conditioning followed by hematopoietic stem cell transplantation (HSCT) can be associated with significant adverse late effects. We report a case series of fiv...
The value of early myeloablative treatment of aggressive lymphoma in adults has been the subject of argument for many years. Before the addition of rituximab to the four-drug regimen known as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), a meta-analysis of randomized trials showed similar survival among patients undergoing up-front autologous stem-cell transplantation and t...
The new coronavirus SARS-CoV-2 has rapidly spread over the world causing disease by WHO called COVID-19, is defining global health crisis of our time and greatest threat we have faced during this century [1]. According to World Health Organizations (WHO) data, in February 2021, almost one hundred fifteen million population been infected with more than two deaths [2]. To date, absence any specif...
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