Mycobacterium tuberculosis is a leading cause of morbidity and mortality worldwide. Mycobacterium tuberculosis infects about one third of world population and tuberculosis remains the most frequent cause of death due to a single infectious disease. Anciently, herbal plants have established home remedies for many of common alignments, diagnostic procedures and preventive measures. Using this str...

The emergence of the global threat of extensively drug-resistant (XDR) Mycobacterium tuberculosis reveals weaknesses in tuberculosis management and diagnostic services. We report the draft genome sequence of the first extensively drug-resistant Mycobacterium tuberculosis strain isolated in Malaysia. The sequence was also compared against a reference strain to elucidate the polymorphism that is ...

pyrazinamide resistance in Mycobacterium tuberculosis The first report from Japan Masahiro Kobayashi; Sadao Aoki; Takefumi Saito MD, PhD; Akio Aono,; Satoshi Mitarai, MD, PhD; Department of Clinical Laboratory, National Hospital Organization Ibarakihigashi Hospital, Ibaraki, Japan; Department of Internal Medicine, National Hospital Organization Ibarakihigashi Hospital, Ibaraki, Japan; Departmen...

In mycobacteria, CycA a D-serine, L- and D-alanine, and glycine transporter also functions in the uptake of D-cycloserine, an important second-line anti-tubercular drug. A single nucleotide polymorphism identified in the cycA gene of BCG was hypothesized to contribute to the increased resistance of Mycobacterium bovis bacillus Calmette-Guérin (BCG) to D-cycloserine compared to wild-type Mycobac...

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid. Prominent features are the very large number of genes (57) encoding polyketide...

Background: Tuberculosis (TB) is a major cause of death worldwide. Finding an effective vaccine against TB is the best way to control it. Several vaccines against this disease have been developed but none are completely protective. The aim of this study was to design and construct a cloning vector containing the Mycobacterium tuberculosis (M. tuberculosis) heat shock protein X (hspX). Metho...

Tuberculosis (TB) is the commonest cause of infection-related death globally. Disseminated tuberculosis a life-threatening disease which results from hematogenous spread Mycobacterium tuberculosis. Genitourinary (GUTB) usually caused as result mycobacteria during initial infection. The patient's clinical presentation may vary asymptomatic to non-specific symptoms related organ involved and also...

A metastatic tuberculous abscess is a rare condition that should be considered in the differential diagnoses of subcutaneous nodules immunosuppressed patients. 71-year-old woman with rheumatoid arthritis developed disseminated tuberculosis due to Mycobacterium bovis. After taking vertebral biopsy, appeared on extremities. Initial histopathological and microbiological studies performed skin biop...

Human alveolar macrophages (AMphi) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive environment for bacterial growth. The present study compared AMphi apoptosis following infection by M. tuberculosis complex strains of differing virulence and by Mycobacterium ...

The Mycobacterium tuberculosis complex includes bovine and human strains of the tuberculosis bacillus, including Mycobacterium tuberculosis, Mycobacterium bovis and the Mycobacterium bovis BCG vaccine strain. M. bovis has evolved from a M. tuberculosis-like ancestor and is the ancestor of the BCG vaccine. The pathogens demonstrate distinct differences in virulence, host range and metabolism, bu...