BACKGROUND & OBJECTIVE The non-tuberculous mycobacteria (NTM) have emerged as important opportunistic pathogens of human beings in the recent years. The NTM are rapid growing mycobacteria (RGM), which include Mycobacterium fortuitum and M. chelonae and grouped as M. fortuitum-chelonae complex. Though there are reports on isolation of NTM from various parts of India, information on its occurrenc...

Infection with Mycobacterium tuberculosis (Mtb) is characterized by localized, roughly spherical lesions within which the pathogen interacts with host cells. Containment of the infection or progression of disease depends on the behavior of individual cells, which, in turn, depends on the local molecular environment and on contact with neighboring cells. Modeling can help us understand the nonli...

We have developed a Real-Time PCR assay to detect M. tuberculosis using the iCycler iQ detection system by TaqMan assay directly on the clinical specimen. A total of 513 clinical samples were taken from patients with suspected tuberculosis and other patients that had an active mycobacterial infection, as well as patients with diagnosed tuberculosis who were receiving antitubercular therapy. The...

To ascertain the cause of tuberculous-like lesions in pigs slaughtered in a local abattoir in Ibadan (south-western Nigeria), a total of 516 pigs were inspected over a period of four months, 18 of which had gross lesions suggestive of tuberculosis at post-mortem. Mycobacterial culture and molecular typing (GenoType Mycobacterium CM [Common Mycobacteria] assay) analysis were used to identify and...

We herein present the third set of documented clinical Mycobacterium setense cases. Three clinically unrelated isolates were identified and characterized using various key conventional and molecular diagnostic tests. Phenotypic and molecular data analysis, particularly 16S rDNA, hsp65, and rpoB sequencing, provided evidence of M. setense involvement in clinical infections in Iranian patients. O...

The proportion of non-tuberculous mycobacteria to Mycobacterium tuberculosis cultivated in the laboratory has been recently increasing. Numerous skin and soft tissue infections have been reported, while osteomyelitis is reported very rarely. A delayed diagnosis can cause a wide range of bone destruction and joint contracture, which highlights the importance of early recognition of osteomyelitis...

Mycobacterium wolinskyi belongs to the Mycobacterium smegmatis group, which comprises rapidly growing non-tuberculous mycobacteria. The number of case reports on M. wolinskyi infections associated with postoperative wounds has increased in recent years. We herein report a case of peritonitis due to M. wolinskyi after peritoneal catheter embedment surgery. Identification was achieved based on 16...

We report the complete genome sequences of 17 rapidly growing nontuberculous mycobacterial (NTM) strains, including 16 Mycobacterium abscessus complex strains and one M. immunogenum strain. These sequences add value to studies of the genetic diversity of rapidly growing NTM strains recovered from human specimens.

Atypical mycobacteria, or more correctly nontuberculous mycobacterial (NTM) species, are a ubiquitous group of environmental organisms that have potential to cause pathological presentations, varying from skin and superficial infections to deeper infections with or without systemic dissemination. Many NTM species are well-recognised pathogens, whereas others are newly emerging and their pathoge...