The prevalence of non-tuberculous mycobacterium (NTM) appears to be increasing. Much of the experience in the literature about this emerging organism comes from specialised units or populations such as cystic fibrosis patients. We, therefore, aim to evaluate the experience in a general respiratory population of dealing with patients with positive culture of NTM. We did a retrospective review of...

................................................................................................................................ xxv Chapter One General Introduction, Aims and Objectives ........................................ 0 1.1 Summary ........................................................................................................................ 1 1.2 The history of medicinal pla...

Mycobacterial species fill a wide variety of evolutionary niches. The most vigorously studied member of the genus is Mycobacterium tuberculosis, the causative agent of human tuberculosis (13). M. tuberculosis was responsible for an estimated 1.6 million deaths worldwide in 2002, making it second to only HIV in mortality attributed to an infectious disease (2). Mycobacterium bovis and Mycobacter...

Amentoflavone and 4' monomethoxy amentoflavone were previously isolated from Garcinia livingstonei leaves. These compounds had good activities (MIC 6 and 8 μg/ml) against some nosocomial bacteria. In this study, the activity of these purified compounds were tested against fast-growing non-pathogenic Mycobacterium smegmatis. Amentoflavone was the most active compound, with an MIC of 0.60 ± 0.70 ...

PATIENT Male, 83 FINAL DIAGNOSIS: Membranous glomerulonephritis Symptoms: Producting cough Medication: - Clinical Procedure: - Specialty: Nephrology. OBJECTIVE Rare disease. BACKGROUND Membranous glomerulonephritis can occur secondarily from infectious diseases. There are no reports describing membranous glomerulonephritis caused by non-tuberculous mycobacterium infection. However, several ...

In mycobacteria, CycA a D-serine, L- and D-alanine, and glycine transporter also functions in the uptake of D-cycloserine, an important second-line anti-tubercular drug. A single nucleotide polymorphism identified in the cycA gene of BCG was hypothesized to contribute to the increased resistance of Mycobacterium bovis bacillus Calmette-Guérin (BCG) to D-cycloserine compared to wild-type Mycobac...

A case is presented of coinfection with Mycobacterium malmoense and Mycobacterium tuberculosis in a Cuban patient with AIDS which produced respiratory and liver disease respectively. Cultures done from sputum samples showed the presence of a non-pigmented, slow growing mycobacterial strain belonging to Runyon group III and identified as Mycobacterium malmoense. From cultures of liver tissue rem...

At the time macrophages phagocyte against Mycobacterium tuberculosis entry, it occurs respiratory burst, and become the initial formation of reactive oxygen species (ROS). Reactive oxygen species such as nitric oxide and oxygen radicals kill the mycobacterium bacteria. However, Mycobacterium tuberculosis has an antioxidant that plays a role in redox homeostasis system which protects itself from...

A standardized clarithromycin susceptibility test for Mycobacterium genavense is reported. The BACTEC radiometric broth dilution test method recommended for Mycobacterium avium complex was modified to develop a reliable and reproducible procedure. Test development involved optimization of medium pH and inoculum densities for antibiotic vials as well as growth control vials. MIC control organism...

background and aims: infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites .the th9 subset develops in response to combined signals from tgf-b and il-4 among a cacophony of other cytokines in the extracellular milieu.t helper 9 (th9) cells,a novel cd4 t cell subset, seem to play a complex role in the outcome of specific immune responses. in this art...