نتایج جستجو برای: mx1
تعداد نتایج: 518 فیلتر نتایج به سال:
Background Type I Interferon (IFN) pathway activation plays a central role in the pathogenesis of several autoimmune conditions. However, limited evidence is available on IFN antiphospholipid antibody (aPL) positive subjects, including aPL carriers and syndrome (APS) patients. In addition, recent evidences have highlighted existence bridging condition between pure primary APS (PAPS) defined sys...
Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection. Using mRNA-seq analysis of HA1800-control cells with HA1800-HHV-6A G...
A mouse model for Down syndrome, Ts1Cje, has been developed. This model has made possible a step in the genetic dissection of the learning, behavioral, and neurological abnormalities associated with segmental trisomy for the region of mouse chromosome 16 homologous with the so-called "Down syndrome region" of human chromosome segment 21q22. Tests of learning in the Morris water maze and assessm...
The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, in adult mice resulted in marked changes in hematopoietic stem and progenitor cell (HSPC) localization. HSPC egressed from BM to spleen after Ext1 deletion. This was associate...
The interaction between human papillomavirus (HPV) and host cells is not well understood. We investigate the early stage of HPV infections by global expression profiling in a cell model, in which HaCaT cells were transfected with HPV11, HPV16 or HPV45 genomes. We report the differential expression of genes not previously implicated in HPV biology, such as the PSG family and ANKRD1, and of genes...
Xenopus laevis adults mount effective immune responses to ranavirus Frog Virus 3 (FV3) infections and clear the pathogen within 2-3 weeks. In contrast, most tadpoles cannot clear FV3 and succumb to infections within a month. While larval susceptibility has been attributed to ineffective adaptive immunity, the contribution of innate immune components has not been addressed. Accordingly, we perfo...
given the knownGPIb/IX/V pathobiology in Bernard-Soulier syndrome and that Mx1-C1 mice have characteristics similar to that syndrome. Clearly, glycosylation of other surface receptors and perhaps other proteins may contribute to the observed defect in thrombopoiesis and may have been missed. The findings of Kudo et al set the stage for further research on the mechanism by which GPIba O-glycosyl...
We report on a direct search for a three-body decay of the orthopositronium into a photon and two penetrating particles, o-Ps → γ +X1 +X2. The existence of this decay could explain the discrepancy between the measured and the predicted values of the orthopositronium decay rate. From the analysis of the collected data a single candidate event is found, consistent with the expected background. Th...
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