BACKGROUND Neuromyelitis optica (NMO) is an inflammatory disease with combined features of optic neuritis and myelitis. This pathologic entity may induce severe disability, including visual loss and paraplegia. Other than clinical follow-up, there is no marker for severity of the disease. OBJECTIVES To evaluate the use of optical coherence tomography (OCT) in NMO and to determine whether this...

Introduction: Many study shown the effectiveness dose enhancement with gold nanoparticles (GNPs), especially with low-energy x-rays. Recently, proton beam radiation therapy (PBRT) has attention as a treatment for tumors. The advantage in PBRT, which releases high dose at the controllable Bragg peak position that localized for Au target and the released dose increased in depth....

Objective: To compare clinical features of pediatric neuromyelitis optica (NMO) to other pediatric demyelinating diseases. Methods: Review of a prospective multicenter database on children with demyelinating diseases. Case summaries documenting clinical and laboratory features were reviewed by an adjudication panel. Diagnoses were assigned in the following categories: multiple sclerosis (MS), a...

Background: There are several methods to detect AQP4-antibody which is essential for diagnosis neuromyelitis optica (NMO). Objective: To evaluate an accuracy of the commercially available kit compared with other available tests. Methods: One hundred and twelve patients who visited the multiple sclerosis (MS) clinic at Siriraj Hospital were tested for AQP4-antibody by cell-based assay with Senda...

Systemic lupus erythematosus (SLE) is an autoimmune disease that can have detrimental effects on many different systems in the body, including the central nervous system. Neuropsychiatric SLE (NPSLE) refers to several different neurological and/or behavioral clinical syndromes, and has been reported as having a prevalence rate of approximately 30−40%, while manifestation of myelitis or optic ne...

BACKGROUND Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that predominantly affects the optic nerves and the spinal cord, and is possibly mediated by an immune mechanism distinct from that of multiple sclerosis (MS). Central scotoma is recognized as a characteristic visual field defect pattern of optic neuritis (ON), however, the differing pathogenic mechanisms of NMO and ...

Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) characterized by severe attacks of optic neuritis and myelitis, and which, unlike multiple sclerosis (MS), commonly spares the brain in the early stages. NMO used to be considered as a special form of MS. During the past 10 years, however, the two diseases have been shown to be clearly different. NMO is a ...