OBJECTIVE To evaluate and update the response and survival outcomes and toxic effects in patients treated with topical nitrogen mustard (mechlorethamine hydrochloride) as primary therapy. DESIGN A single-center, retrospective cohort analysis. SETTING Academic referral center for cutaneous lymphoma. PATIENTS A total of 203 patients with mycosis fungoides (clinical stages I-III) treated wit...

Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold receptor transient receptor potential channel, subfamily A, member 1 and may thus induce energy expenditure and metabolic changes.Objective: The objective of our study was to evalua...

There have been reports of chemical attacks in which sulfur mustard might have been used (a) on Iranian soldiers and civilians during the Gulf War in 1984 and 1985 and (b) in an Iraqi chemical attack on the Iranian-occupied village of Halbja in 1988, resulting in many civilian casualties. Heavy use of chemical warfare in Afghanistan by the Soviet military is a recent innovation in military tact...

The systemic use of thiol-containing uroepithelial protecting agents, e.g., N-acetylcysteine (NAC) or mesna, in conjunction with the alkylating agent cyclophosphamide is predicated on the assumption that the toxic metabolic by-products will be consumed by thiol without diminishing the cytotoxicity of the active alkylating intermediate, phosphoramide mustard. Studies in murine tumor systems have...

Many works were made on the biological application of mustard gas and nitrogen mustard. The mechanism of the biological action of mustards , however, remains largely unknown, and many experimental results have been accumulated to, suggest its mode of actions(1) , among which much attention has been called to the analogy of its action to those of X-ray irradiation or of hydrogen peroxide(2). Her...

One of the sources of evidence for the somatic mutation hypothesis of cancer is in studies of cor relation between mutagenic and carcinogenic ca pacities of physical and chemical agents. Tests in this laboratory have suggested a positive correla tion within the limits of three mustard compounds. Both the nitrogen mustard, methylbis (2-chloroethyl)amine hydrochloride, and sulfur mustard, bis(2-c...

Among the oilseeds grown around the world, mustard is one of the important crop worldwide due to its wide adaptability and high yielding capacity. Owing to the importance of its utilities as condiment, cooking oil and some medical aids, the demand for its seed production is too high. The present study was carried out to evaluate the impact of Mr. Trivedi’s biofield energy treatment on mustard (...

The bifunctional alkylating anticancer drug nitrogen mustard forms a variety of DNA lesions, including monoadducts and intrastrand and interstrand crosslinks. Although it is known that nucleotide excision repair (NER) is important in processing these adducts, the role of the other principal excision repair pathway, base excision repair (BER) is less well defined. Using isogenic Saccharomyces ce...

the use of more competitive species and cultivars in small grain cereal production may help to develop production systems that require less herbicide. this study was designed to identify root and shoot characteristics of cereal seedlings that would allow distinguishing the more competitive (mc) cultivars from the less competitive (lc) ones. two growth cabinet trials were conducted using four cr...

in this study the role of glutathione (gsh) in sulfur mustard -induced oxidative stress and cytotoxicity, in human skin fibroblast cell line (hf2ff) was evaluated. sulfur mustard-induced superoxide radical and hydrogen peroxide formation were evaluated by determination of superoxide dismutase and catalase activity in cell lysate. the cytotoxicity of sulfur mustard was estimated by lactate dehyd...