The muscular dystrophies comprise a heterogeneous group of genetic disorders that produce progressive skeletal muscle weakness and wasting. There has been rapid growth and change in our understanding of these disorders in recent years, and advances in basic science are being translated into increasing numbers of clinical trials. This review will discuss therapeutic developments in 3 of the most...

For understanding of human posture control, changes in muscular activity caused by changes in sensory inputs are very important because the control mechanism is complicated with integrating multi-inputs and outputting various and simultaneous muscular activity. In this research, we aim to obtain quantitative changes in muscular activity caused by changes in sensory inputs. For this purpose, we ...

Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidant supplementation was shown to be effective in the treatment of multiple disea...

Muscular dystrophy is one of the rare diseases that cause progressive weakness and degeneration of skeletal muscles used during voluntary movement. There are many different types of muscular dystrophy based on the age of onset, severity and pattern of inheritance, of which duchenne and becker muscular dystrophies being more prevalent. The absence or abnormality of dystrophin, a protein which fo...

Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organization of membrane attachment complexes. Loss of the Thbs4 gene causes spontaneous dystrophic ch...

BACKGROUND Sub-muscular positioning of breast implants requires interrupting as well as disinserting both the abdominal and sterno-chondral fibers of the pectoral muscle; this can produce a muscular strength reduction which reveal bothering and is often detected in some daily motions, such as cutting bread into slices. MATERIAL AND METHODS The revision of anatomy and literature induced the au...

A eletroestimulação neuromuscular é uma corrente de média frequência aplicada para promover contração muscular com finalidade hipertrofia e aumento força. O objetivo foi avaliar os efeitos da russa em mulheres déficit força abdome. Foram selecionadas dez mulheres, entre 18 40 anos, divididas dois grupos: um fraqueza reto abdominal o outro, além fraqueza, também tiveram pelo menos gestação. 24 s...

La tasa de filtración glomerular (TFG) es el producto del número nefronas multiplicado por la media una sola nefrona. Esta medida en adulto mayor, está condicionada serie factores que conllevan al diagnóstico erróneo enfermedad renal, sin tomar cuenta los cambios sufre riñón con envejecimiento. El uso diferentes marcadores endógenos como creatinina sujeta a disminución masa muscular y dieta, em...

RESUMO Objetivos Avaliar preditores de dismorfia muscular em homens brasileiros minoria sexual e gênero descrever normas comunitárias para o Muscle Dysmorphic Disorder Inventory (MDDI), instrumento avaliação sinais sintomas muscular. Métodos Trata-se estudo transversal realizado com 1.444 gênero, idade entre 18 50 anos. Por meio uma pesquisa on-line , os participantes responderam a um questioná...