Lower extremity neuromuscular fatigue purportedly increases anterior cruciate ligament (ACL) injury risk through promotion of extreme landing mechanics. However, the impact of fatigue on muscle groups critical to the landing strategy remains unclear. This study examined the effects of isolated hip rotator and triceps surae fatigue on lower extremity landing biomechanics. Sixteen healthy females...

The purpose of this study was to determine the effect of respiratory muscle fatigue on intercostal and forearm muscle perfusion and oxygenation in patients with heart failure. Five clinically stable heart failure patients with respiratory muscle weakness (age, 66±12 years; left ventricle ejection fraction, 34±3%) and nine matched healthy controls underwent a respiratory muscle fatigue protocol,...

This study investigated the effect of initial muscle glycogen on performance of repeated sprints and some potential mechanisms for an effect of glycogen on fatigue. Eight subjects performed 2 cycling trials (repeated 60-s sprints) following consumption of either a high carbohydrate (HC) or a low carbohydrate (LC) diet. Muscle biopsies and blood samples were collected at baseline, following a 15...

Linear polarized near-infrared light (PL) irradiation is considered one of the useful methods for muscle fatigue recovery, because it increases the blood flow and skin temperature of the irradiated part. The purpose of this study was to examine the effect of PL-irradiation on muscle fatigue recovery and physiological response in the upper limbs after maximal repeated rhythmic hand gripping (RRH...

Prolonged exhaustive submaximal exercise in humans induces marked metabolic changes, but little is known about effects on muscle Na+-K+-ATPase activity and sarcoplasmic reticulum Ca2+ regulation. We therefore investigated whether these processes were impaired during cycling exercise at 74.3 +/- 1.2% maximal O2 uptake (mean +/- SE) continued until fatigue in eight healthy subjects (maximal O2 up...

BACKGROUND Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. METHODS A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorec...

Carbonic anhydrase III (CAIII) is a metabolic enzyme and a regulator for intracellular pH. CAIII has been reported with high level expression in slow twitch skeletal muscles. Here we demonstrate that CAIII is expressed in multiple slow and fast twitch muscles of adult mouse independent of the expression of myosin isoforms. Expressing similar fast type of myofilament proteins, CAIII-positive tib...

Congestive heart failure refractory to medical therapy can be managed with cardiac transplantation or artificial heart. Due to the scarcity of donor organs and unsatisfactory longterm outcomes of mechanical devices, skeletal muscle has been used to augment circulatory function. Dynamic cardiomyoplasty, skeletal muscle ventricle, aortomyoplasty, and muscle powered assist devices all require the ...

The electromyographic activity of the paraspinal muscles at four levels were examined to investigate the effects of chair sitting on muscle activation patterns and muscle fatigue. The Balans, Nada-Chair Back Up, and Standard Office Chair were studied. Twenty four subjects were asked to engage in a seated writing task for 10 minutes for each of three chairs. Prior to the first writing period and...

BACKGROUND Biomarkers of peripheral muscle fatigue (BPMFs) are used to offer insights into mechanisms of exhaustion during exercise in order to detect abnormal fatigue or to detect defective metabolic pathways. This review aims at describing recent advances and future perspectives concerning the most important biomarkers of muscle fatigue during exercise. RESULTS BPMFs are classified accordin...