A collaborative study has been carried out to establish the precision and accuracy of five test systems for the assessment of the toxicity of whole cell pertussis vaccine. To this end, six vaccines, including both "normal" and "abnormal" products with respect to arbitrary levels of Pertussis toxin and/or potency were tested. The study included in vivo test systems as the Mouse Weight Gain (MWG)...

An indirect solid-phase radioimmunoassay (RIA) was applied to titration of serum and cerebrospinal fluid (CSF) antibodies against a variety of viruses including rubella, mumps, measles, herpes simplex, varicella-zoster, and vaccinia. The test used fixed, virus-infected cells as a source of antigen, and conditions for optimal production of viral antigen were determined for each virus-host cell s...

BACKGROUND Before the widespread use of vaccine, mumps was the most common cause of viral meningitis (up to 10% of mumps infections). Vaccination programs have resulted in a drop of more than 99% in the number of reported mumps cases in the United States and Canada. Although rare in Canada, outbreaks have recently occurred throughout the world, including a large outbreak in the United Kingdom, ...

THIS REPORT concerns a patient who died of severe congestive cardiac failure 8 months after the onset of a clinical illness indistinguishable from mumps, characterized by submaxillary gland enlargement, orchitis, pancreatitis, meningitis, and myocarditis. During the past 2 decades, several papers have appeared describing electrocardiographic changes in many patients with mumps,1-5 and clinical ...

Cyclical outbreaks of mumps have been noticed across Chandigarh city during winter months. Chandigarh does not provide measles, mumps and rubella (MMR) vaccination in the State immunization schedule. Epidemiological shift in age at diagnosis of mumps was noticed with higher incidence in older children and adults. Increased occurrence of complications can be predicted with this age shift. Silent...

THIS REPORT concerns a patient who died of severe congestive cardiac failure 8 months after the onset of a clinical illness indistinguishable from mumps, characterized by submaxillary gland enlargement, orchitis, pancreatitis, meningitis, and myocarditis. During the past 2 decades, several papers have appeared describing electrocardiographic changes in many patients with mumps,1-5 and clinical ...

BACKGROUND Despite high levels of triple MMR vaccinations being recorded on Spain, epidemic mumps outbreaks are still being reported. This study is aimed at describing an outbreak reported in the province of Almeria in 2005 and of evaluating the degree to which the vaccinated population was affected. METHODS Descriptive study of reported cases. VARIABLES STUDIED Basic Health District, munic...

OBJECTIVE The objective of this study was to determine the prevalence of IgG antibodies against mumps in a representative stratified sample of children under 18 years of age in Pleven district, Bulgaria. STUDY DESIGN Cross sectional study. MATERIALS AND METHODS A cross-sectional, sero-epidemiologic survey of 132 children aged under 18 years was conducted in Pleven district. They were distri...

Attempts were made to establish an authentic method for assay of the antilethal potency of Habu antivenine. In spite of its wide use the expression of the antivenine potency in •ganimal nimal unit•h is not reasonable. The expression of the antivenine potency as the relative potency is not valid either so far as a crude venom is used as test toxin, since the neutralization curves of various anti...

In the present study, immunity against infectious diseases, which are capable of influencing both the mother and fetus during pregnancy and the infant in the postnatal period, were assessed in pregnant women to elucidate the necessity of vaccination during the childbearing age. It was determined that there was a trend of increases in the proportion of patients that had low antibody titers obser...