Patients and Methods We retrospectively assessed a single-centre cohort of 569 primary 36 mm MoM Pinnacle THAs (all Corail stems) followed up since 2012 according to Medicines and Healthcare Products Regulation Agency recommendations. All-cause failure rates (all-cause revision, and non-revised cross-sectional imaging failures) were calculated, with predictors for failure identified using multi...

Methods We retrospectively evaluated 140 consecutive patients with NICM who underwent delayed hyperenhancement cardiac MRI between 2002 and 2009. A Cox proportional hazards model was used to evaluate the association between RVEF and the composite outcome of death, left ventricular assist device implantation, or heart transplantation. Predictors of RVEF were evaluated using a multivariable linea...

Inflammation and non-steroidal anti-inflammatory agents (NSAIDs) may play important role in ovarian cancer. However, epidemiologic data are inconsistent, possibly reflecting inter-individual genetic differences affecting the metabolism of NSAIDs. We examined whether common polymorphisms affecting the metabolism of NSAIDs modify the association between NSAIDs and ovarian cancer risk. We genotype...

Methods HIV-infected subjects followed at the Infectious Disease Department of IRCCS San Raffaele, with at least one PTH plasma value and a contemporary CVR determination. CVR was calculated according to Framingham 10years equation (Anderson et al.) Cochran-Armitage test for trend and Spearman correlation were calculated at univariate analysis. Logistic regression was applied at multivariable a...

1. Residuals from linear regressions are used frequently in statistical analysis, often for the purpose of controlling for unwanted effects in multivariable datasets. This paper criticizes the practice, building upon recent critiques. 2. Regression of residuals is often used as an alternative to multiple regression, often with the aim of controlling for confounding variables. When correlations ...

We performed a case-control study to evaluate the association between antibiotic use and Clostridium difficile-associated diarrhea (CDAD), matching for admission unit and time at risk for CDAD. A multivariable regression model showed that treatment with fluoroquinolones (odds ratio 12.7; 95% confidence interval 2.6 to 61.6) was the strongest risk factor for CDAD.

METHODS: We analyzed data from our institution’s prospectively collected National Cancer Institute-Designated Comprehensive Cancer Center Tumor Registry. We used the Chi-squared test and multivariable logistic regression to estimate associations between race/ethnicity, insurance type, age, and breast reconstruction rate. Likelihood-ratio tests assessed the interaction between these associations...