| The generalized likelihood ratio (GLR) test is a widely used method for detecting abrupt changes in linear systems and signals. In this paper the marginalized likelihood ratio (MLR) test is introduced for eliminating three shortcomings of GLR, while preserving its applicability and generality. Firstly, the need for a user-chosen threshold is eliminated in MLR. Secondly, the noise levels need ...

We examine the class of multi-linear representations (MLR) for expressing probability distributions over discrete variables. Recently, MLRs have been considered as intermediate representations that facilitate inference in distributions represented as graphical models. We show that MLR is an expressive representation of discrete distributions and can be used to concisely represent classes of dis...

Over the years development of selective estrogen receptor (ER) ligands has been of great concern to researchers involved in the chemistry and pharmacology of anticancer drugs, resulting in numerous synthesized selective ER subtype inhibitors. In this work, a data set of 82 ER ligands with ERα and ERβ inhibitory activities was built, and quantitative structure-activity relationship (QSAR) method...

Dichloroacetate (DCA) is a simple and small anticancer drug that arouses the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA can selectively promote mitochondria-regulated apoptosis, depolarizing the hyperpolarized inner mitochondrial membrane potential to normal levels, inhibit tumor growth and reduce proliferati...