OBJECTIVE To describe the patterns of cortical and subcortical changes in amyotrophic lateral sclerosis (ALS) stratified for the C9orf72 genotype. METHODS A prospective, single-center, single-protocol, gray and white matter magnetic resonance case-control imaging study was undertaken with 30 C9orf72-negative patients with ALS, 9 patients with ALS carrying the C9orf72 hexanucleotide repeat exp...

BACKGROUND Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis. PURPOSE To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa. MATERIAL ...

Prostate cancer is one of the most common malignancies in men, generally with a slow growth rate and early detection is essential for a complete treatment. Multiparametric magnetic resonance imaging (MP MRI) lead to a better choice of therapy by improving detection and staging of prostate cancer. Conventional sequences are useful to evaluate prostate cancer in the peripheral zones; functional a...

Magnetic resonance imaging (MRI) provides excellent soft tissue contrast, and in combination with its quantitative functional imaging capability, this modality is ideal for use in radiotherapy. MRI images, either used directly or fused with CT, play an increasingly important role in contouring gross tumor volume (GTV) and organs at risk (OAR) in radiation treatment planning (RTP) systems. The s...

Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anatomic and functional imaging using established criteria for the delineation of ...

Background Conventional magnetic resonance imaging (MRI) has limitations in differentiating tumor recurrence (TR) from radionecrosis (RN) high grade gliomas (HGG), which can present with morphologically similar appearances. Multiparametric advanced MR sequences and Positron Emission Tomography (PET) amino acid tracers aid diagnosing metabolism. The role of both modalities on an individual basis...

Purpose To evaluate transrectal (TR) and transperineal (TP) approaches for MRI/ultrasound (MRI/US) fusion-guided biopsy to detect prostate cancer (PCa). Materials and Methods 154 men underwent multiparametric MRI and MRI/US fusion-guided biopsy between July 2012 and October 2016. 79/154 patients were biopsied with a TR approach and 75/154 with a TP approach. MRI was retrospectively analyzed a...

OBJECTIVE To determine whether prostate image reporting and data system (PIRADS) 3 lesions as assessed by a 3T multiparametric magnetic resonance imaging (MRI) represent clinically significant prostate cancer. METHOD A retrospective review was performed on a series of consecutive patients who underwent MRI guided biopsy of the prostate for clinical suspicion of prostate cancer between January...

A novel deep learning architecture (XmasNet) based on convolutional neural networks was developed for the classification of prostate cancer lesions, using the 3D multiparametric MRI data provided by the PROSTATEx challenge. End-to-end training was performed for XmasNet, with data augmentation done through 3D rotation and slicing, in order to incorporate the 3D information of the lesion. XmasNet...

I note the short communication by Turkbey and Choyke providing a succinct summary of the updated PI-RADS system for prostate MRI acquisition and interpretation in the September-October 2015 issue of Diagnostic and Interventional Radiology. (1). An interesting argument has also been presented against the routine use of dynamic contrast-enhanced (DCE) sequences suggested therein for multiparametr...