This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3-dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic co...

• A 5-component reduced mechanism for diesel-biodiesel-gasoline blends is proposed. Multiple DRG, DRGEP and FSSA methods are applied on the detailed mechanisms. Cross-reactions Arrhenius parameters optimisation techniques analysed. Reduced multicomponent mechanisms validated against literature data. Multicomponent accurately replicates ignition-related characteristics. In this study, a compact ...

In this study, silica nanoparticles were used as support to prepare a new heterogeneous catalyst system for application in organic reactions. The reaction of silica nanoparticles with sodium 2-bromoethane-1-sulfonate resulted in the connection of a sulfonic acid group on the surface of silica nanoparticles (NSESA). The synthetic catalyst system was characterized using different microscopic and ...

Three UV spectrophotometric methods have been developed, simultaneous equation method, multicomponent analysis (II) and derivative spectroscopy method (III). The absorption maxima of the drugs were found to be 247, 259 and 272 nm, respectively for efavirenz, tenofovir disoproxil fumarate and lamivudine in methanol:water (50:50) solvent system. Efavirenz, tenofovir disoproxil fumarate and lamivu...

The development of multicomponent reactions (MCRs) designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. A comparative study of the synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarc...

Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically re...

Stevens, M. 2016. Multicomponent Reactions in C/C Chemistry. – Targeting the Angiotensin II Subtype 2 Receptor. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 219. 93 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9636-4. Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, su...