The desire to understand tumor complexity has given rise to mathematical models to describe the tumor microenvironment. We present a new mathematical model for avascular tumor growth and development that spans three distinct scales. At the cellular level, a lattice Monte Carlo model describes cellular dynamics (proliferation, adhesion, and viability). At the subcellular level, a Boolean network...

Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na+/H+ exchanger NHE1 is an important modifier of the tumour nanoenvironment. Here we tested the modulation of cell-cell-adhesion by extracellular pH and NHE1. MV3 tumour sp...

Cell culture models are excellent tools for potential toxicity of nanoparticles and fundamental investigations in cancer research. Thus, information about AuNP potential toxicity and effects on human health is necessary for the use of nanomaterials in clinical settings. The aim of our research is to examine the effects of AuNPs on the epithelial origin cell lines: continuous and oncogenic. Embr...

Background: Radiotherapy is an established therapeutic modality for prostate cancer. Resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. No data is available on the response of cellular spheroid to Reseveratol. In this study we have examined the effect of Resveratol on the radiation response of human p...

Three-dimensional (3D) in vitro models have been used in cancer research as an intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical cancer models represent major 3D in vitro models that have been described over the past 4 decades. These models have gained popularity in cancer stem cell research using tumorospheres. Thus, it is crucial to define and clarify ...

Purpose: To analyze the capabilities of different classical mathematical models to describe growth multicellular spheroids simulated with an on-lattice agent-based Monte Carlo model that has already been validated. Methods: The exponential, Gompertz, logistic, potential, and Bertalanffy have fitted in situations volume data generated a simulates spheroid growth. Two samples pseudo-data, obtaine...

The synthesis, characterization and biological activity of tungstenocenes with varying biologically active (O,O–), (S,O–) (N,O–) chelates are described. Complexes were characterized by 1H 13C NMR, elemental analysis, ESI-mass spectrometry, FT-IR spectroscopy X-ray diffraction analysis. aqueous stability was studied UV/Vis the WIV to WV process cyclic voltammetry. cytotoxicity determined MTT ass...

Hepatocellular carcinoma (HCC) is a highly metastatic primary liver cancer generating molecular alterations that end up escaping the apoptotic machinery and conferring multidrug resistance. Targeted medicines with increased selective cytotoxicity minimal drug resistance are essential for treatment of HCC. In this study, self-assembled polycationic (PC) amphiphilic β-cyclodextrin (βCDC6) nanopar...

The aggressive nature of a tumor is presumably its inherent one, but different environmental cues can manipulate it in many ways. In this context, the influence metabolic stresses on behavior needs to be analyzed understand their far-reaching implications aggression and dormancy. This work investigates facets tumor, such as tumorigenic capacity, phenotype, migration, under multiple stress condi...