The treatment of B-cell malignancies has been revolutionized by the availability of safe and effective monoclonal antibodies. The addition of rituximab to standard chemotherapy regimens prolongs the survival ofpatients with diffuse large B-cell lymphoma (DLBCL) and follicular non-Hodgkin lymphoma. Nevertheless, indolent and mantle cell lymphomas remain incurable, and 30% to 40% of patients with...

Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a variety of malignancies. Therefore, this review catalogs recent advances in natu...

Acute lymphoblastic leukemia (ALL) affects both children and adults, with prevalence between the ages of 2 and 5 years. Serial clinical trials have resulted in steady improvement in the outcome of patients with ALL. Most children and over a third of adult patients are cured with widely available treatment approaches based on the use of risk-directed multiagent chemotherapy regimens and diligent...

Organization-based Multiagent Systems (OMAS) have been viewed as an effective paradigm for addressing the design challenges posed by today’s complex systems. In those systems, the organizational perspective is the main abstraction, which provides a clear separation between agents and systems, allowing a reduction in the complexity of the overall system. To ease the development of OMAS, several ...

PURPOSE Desmoplastic small round cell tumor (DSRCT) is a rare aggressive malignancy that occurs in a young population with a male predominance. We studied the clinical and pathological characteristics of DSRCT and investigated the effects of multimodal therapy including aggressive surgical resection, induction chemotherapy, and external beam radiotherapy. METHODS We retrospectively reviewed a...

Proliferation of multiagent application in business domains prompts increasing studies in MIBIS (Multiagent-based Integrative Business Information Systems) development. Recently, MibML (Multiagent-based Integrative Business Modeling Language) has been proposed as a conceptual-modeling grammar for the MIBIS universe. In this paper, we investigate the MibML grammar from the perspective of the BWW...

This paper presents a solution to help new composers make harmonies. A multiagent approach based on virtual organizations has been used to construct this application. This model is built by using a multiagent system. This study presents a Multi-Agent System (MAS) built with PANGEA, a platform to develop different multiagent systems, capable of composing music following the HS algorithm. The res...

This paper discusses specific features of planning in multiagent domains and presents concepts for a multiagent extension of PDDL, the Multiagent Planning Language MAPL (“maple”). MAPL uses non-boolean state variables and thus allows to describe an agent’s ignorance of facts as well as a simplified mutex concept. The time model of MAPL is based on Simple Temporal Networks and allows both quanti...