The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

measuring and comparing grip and pinch strengths with their normative data is a valid method to detect intensity of the numerous damages of hand. this research was carried out with the aim of establishing normative data of grip strength and three types of pinch strengths (tip, key and palmar) in healthy iranian adults.in this cross-sectional study, the study population was formed of 1008 people...

The urgent need for new green and sustainable models is ground the current demand of innovative renewable resource based pharmaceutical products. We propose a Rojo Duro skin onion extract loaded poloxamer/chitosan spray mucoadhesive thermogel aimed at solving limitations in oral mucosits treatment. Being among main side effects radio- chemotherapy, effective treatment buccal lesions still repre...

A new drug delivery system for H2 receptor antagonist Ranitidine hydrochloride, was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of tim Floating-Mucoadesive tablets of Ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ra...

The vagina has been studied as a favorable site for local and systemic delivery of drugs for female-related conditions. There are a large number of vaginal medications on the market and most of them require frequent application due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising a...

Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...

the purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934p as mucoadhesive polymer and ethyl cellulose as carrier ...

Rahul Nair*, B.Haritha Reddy C.K.Ashok Kumar, K.Jayraj Kumar. 1.Sree Vidyanikethan College of Pharmacy, A.Rangampet, Chittoor District Tirupathi, Andhra Pradesh. 2. D.R.Karigowda College of Pharmacy Hassan. Karnataka. ______________________________________________________________________________________ ABSTRACT Chitosan (CS) is a naturally occurring polymer which finds a wide array of pharmace...

A recent concept of polypill has evolved to include a number of key drugs in a single pill that can be used to prevent various diseases, especially cardiovascular diseases. Modeled economic analyses propose that such multidrug regimen would be cost effective in reducing the cardiovascular diseases in developing countries like India and Pakistan. Recently it has been recognized by Combination Ph...