OBJECTIVE The goal of our study was to identify the regulatory mechanisms of gene expression mediated by miRNAs and DNA methylation in colon adenocarcinoma (COAD). MATERIALS AND METHODS   The miRNAs and mRNAs expression and DNA methylation data of COAD and adjacent normal tissues were obtained from The Cancer Genome Atlas (TCGA) database. Based on the differentially expressed miRNAs and mRNAs...

The PIAS family of proteins was named based on the identification of the founding member, PIAS3, as a repressor of the activity of the STAT3 transcription factor (Protein Inhibitor of Activated STAT) (Chung et al. 1997). Since then, three additional family members— PIAS1, PIASy, and PIASx—have been identified and are characterized by a high degree of sequence conservation throughout the protein...

The follicular dermal papilla (DP) is a specialized hair mesenchymal cell that plays pivotal roles in follicle (HF) development and morphogenesis. Although transcriptome data exists for HF, characterization of human DPs at the single-cell level has been unsatisfactory due to limited number DP cells under dissociation condition. To generate high proportion cells, we manually isolated anagen HFs ...