Background Gout is a chronic inflammatory disease featuring the deposition of monosodium urate (MSU) crystals in synovial fluid patients, followed by NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome activation bioactive IL-1β release, which recruits neutrophils to local inflammation sites. Blocking function becoming potent therapeutic approach for gout gouty arthritis. Conv...

Two hundred and fifty six unselected women, 50 of whom had urinary symptoms (frequency of urination or dysuria, or both), and who were attending a department of genitourinary medicine, were investigated. The urinary symptoms were associated both with pyuria and the isolation of undoubted pathogens from midstream urine (MSU) specimens. No associations were found between urinary symptoms and the ...

Gout is an inflammatory arthritis characterized by red, tender, hot and tumid joints. The development cause and process of gout is very sophisticated; recent studies, notwithstanding, have offered novel perspectives on the mechanism from an immunological viewpoint. The pathological process of gout involves both innate and adaptive immune responses. Other studies have demonstrated that gout deve...

Diverse causes, including pathogenic invasion or the uptake of mineral crystals such as silica and monosodium urate (MSU), threaten cells with lysosomal rupture, which can lead to oxidative stress, inflammation, and apoptosis or necrosis. Here, we demonstrate that lysosomes are selectively sequestered by autophagy, when damaged by MSU, silica, or the lysosomotropic reagent L-Leucyl-L-leucine me...

Abstract We present a new version (v5.0) of the NOAA Center for Satellite Applications and Research (STAR) mid‐tropospheric temperature (TMT) time series. This data set uses backward‐merging approach to intercalibrate 16 satellite‐based microwave sounding records. The instrument observations included those from Microwave Sounding Unit (MSU) during 1979–2004, Advanced Unit‐A (AMSU‐A) 1998–2017, ...

[1] IPCC (Intergovernmental Panel on Climate Change) AR4 (Fourth Assessment Report) GCMs (General Circulation Models) predict a tropical tropospheric warming that increases with height, reaches its maximum at ∼200 hPa, and decreases to zero near the tropical tropopause. This study examines the GCM‐predicted maximum warming in the tropical upper troposphere using satellite MSU (microwave soundin...