Background There are no effective treatments for multiple system atrophy (MSA). Objective The objective of this study was to assess the efficacy and safety serotonin reuptake inhibitor fluoxetine (40 mg/d) symptomatic treatment MSA. Methods This a double-blind, parallel-group, placebo-controlled, randomized trial in patients with “probable” primary outcome change from baseline week 12 mean tota...

Neuronal cytoplasmic inclusions (NCIs) were demonstrated by means of silver staining (Gallyas staining) in the central nervous systems of 18 deceased patients with multiple system atrophy (MSA) - 6 with olivopontocerebellar atrophy (OPCA), 6 with striatonigral degeneration (SND) and 6 with Shy-Drager syndrome (SDS). We observed NCIs in the cerebral cortex, putamen, pons, medulla oblongata and s...

Mined Semantic Analysis (MSA) is a novel distributional semantics approach which employs data mining techniques. MSA embraces knowledge-driven analysis of natural languages. It uncovers implicit relations between concepts by mining for their associations in target encyclopedic corpora. MSA exploits not only target corpus content but also its knowledge graph (e.g., "See also" link graph of Wikip...

Multiple system atrophy (MSA) is one of the few neurodegenerative disorders where we have a significant understanding of the clinical and pathological manifestations but where the aetiology remains almost completely unknown. Research to overcome this hurdle is gaining momentum through international research collaboration and a series of genetic and molecular discoveries in the last few years, w...

Parkinson plus diseases, comprising mainly progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are rare neurodegenerative conditions. We designed a double-blind randomized placebo-controlled trial of riluzole as a potential disease-modifying agent in Parkinson plus disorders (NNIPPS: Neuroprotection and Natural History in Parkinson Plus Syndromes). We analysed the accuracy of...

Treatment of a newly prepared digold(i) complex, [Au2(dppe)(H2msa)2] ([H41]; dppe = 1,2-bis(diphenylphosphino)ethane, msa = thiomalate), with Ni(2+) gave two interconvertible multinuclear complexes, [Ni{Au2(dppe)(msa)2}](2-) ([2](2-)) and [Ni3{Au2(dppe)(Hmsa)2}{Au2(dppe)(msa)2}(MeOH)3] ([3]), dependent on solution acidities.

The present study aimed to measure sensory nerve conduction velocity (SNCV) and muscle sympathetic nerve activity (MSA) in both normal subjects and patients with lumbar spinal canal stenosis (LSCS), and to determine what sensory and sympathetic nerve systems relate to the development of abnormal sensation in the lower limbs of the patients. The study population was 12 patients and 10 age-matche...

Many filamentous fungi produce polyketide molecules with great significance as human pharmaceuticals; these molecules include the cholesterol-lowering compound lovastatin, which was originally isolated from Aspergillus terreus. The chemical diversity and potential uses of these compounds are virtually unlimited, and it is thus of great interest to develop a well-described microbial production p...

We investigated the role of alpha-adrenergic antagonists and clonidine injected into the medial septal area (MSA) on water intake and the decrease in Na+, K+ and urine elicited by ANGII injection into the third ventricle (3rdV). Male Holtzman rats with stainless steel cannulas implanted into the 3rdV and MSA were used. ANGII (12 nmol/ micro l) increased water intake (12.5 +/- 1.7 ml/120 min). C...

BACKGROUND Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unclear whether this effect of coffee is related to caffeine or other substance(s) also c...