• “Evolution of Postmenopausal Hormone Therapy Between 2002 and 2009” by Bruce Ettinger, MD, Sharon M. Wang, PharmD, MS, R. Scott Leslie, MPH, et al. • “A Decade of Postmenopausal Hormone Therapy Prescribing in the United States: LongTerm Effects of the WHI” by Amy Steinkellner, PharmD, Shannon Denison, MA, Sandra Eldridge, PharmD, et al. • “Hormone Therapy Prescribing Trends in the Decade Afte...

Forty-five years ago the first large multicentre, randomized, double-blinded, controlled trial of a potential therapy for multiple sclerosis (MS) was completed testing corticotrophin versus placebo. It demonstrated the feasibility of such a trial in an illness which is as variable, from patient to patient, as MS. Adrenocorticotrophic hormone was soon replaced by intravenous methylprednisolone (...

OBJECTIVE To identify promising candidate genes linked to interindividual differences in the efficacy of interferon beta therapy. Recombinant interferon beta therapy is widely used to reduce disease activity in multiple sclerosis (MS). However, up to 50% of patients continue to have relapses and worsening disability despite therapy. DESIGN We used a genome-wide pharmacogenomic approach to ide...

Infection with JC virus (JCV) is not noticeable and is usually inconsequential. Natalizumab therapy, however, blocks the very late antigen-4 adhesion molecule on immune cells, preventing them from attaching to vascular cell adhesion molecule-1 on brain endothelial cells and then penetrating into the CNS. The dearth of T cells, and perhaps other factors, allows JCV to infect oligodendroglia and ...

Therapeutic drug monitoring is an esential tool for a positive management therapy. The prefered laboratory strategy is immunoassay. Due to the cross-reactivity to other components, alternative approaches, such as LC-MS, are continously under investigation. The paper described briefly the main aspects regarding LC-MS apparatus and technique and recent applications on therapeutic drug monitoring,...

patients and methods this cross-sectional study on 71 patients with ms was carried out between 2010 and 2012, in an iranian population. demographic and pharmacological variables were recorded in d-base. statistical analyses were performed using spss for windows. results the females/males sex ratio within the study population was 3.17: 1. the mean age of females was 32.2 years old (range 20 - 45...