PURPOSE Metabolic changes upon antiangiogenic therapy of recurrent glioblastomas (rGBMs) may provide new biomarkers for treatment efficacy. Since in vitro models showed that phospholipid membrane metabolism provides specific information on tumor growth we employed in-vivo MR-spectroscopic imaging (MRSI) of human rGBMs before and under bevacizumab (BVZ) to measure concentrations of phosphocholin...

BACKGROUND AND PURPOSE Diffuse axonal injury (DAI) after traumatic brain injury (TBI) is important in patient assessment and prognosis, yet they are underestimated with conventional imaging techniques. We used MR spectroscopic imaging (MRSI) to detect DAI and determine whether metabolite ratios are accurate in predicting long-term outcomes and to examine regional differences in injury between c...

Introduction: Treatment of patients with oligodendrogliomas depends on their histopathological grade and cytogenetic profile. Oligodendrogliomas with 1p and 19q loss of heterozygosity (LOH) are known to be more sensitive to the chemotherapy. In the present study, we evaluated the utility of perfusion weighted imaging (PWI) and multivoxel proton magnetic resonance spectroscopy (H MRS) in differe...

Introduction Magnetic Resonance Spectroscopic Imaging (MRSI) is a powerful technique to gain insight into physiological processes in the human body. Since 2D MRSI examinations typically last excessively long, the use of acceleration techniques is of great importance. Here, we use a SENSE approach [1, 2, 3]. The Spatial Response Function (SRF) indicates which spatial areas contribute to the fina...

Introduction: MR spectroscopic imaging (MRSI) provides invaluable information regarding in vivo metabolic processes to aid in clinical diagnosis. However, long scan times are required to resolve both the spatial and spectral dimensions. Fast imaging trajectories, such as EPI [1] and spiral [2], can encode multiple dimensions at once, providing a reduction in scan time compared to conventional M...

This review focuses on the current literature directed towards the brain metabolite findings in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) disease using magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI). Using search terms "metabolites", "spectroscopy", and "CADASIL", six articles were found on Pub...

Introduction Quantification of metabolite concentrations from spectroscopic images has been performed by a variety of approaches: Absolute quantification based on internal water referencing [1] is the current method of choice. It accounts for B1 variations across the field of view but imposes problems when assessing diseases that lead to alteration of tissue water concentration [2] and relaxati...

OBJECTIVE To study the MRI findings of the normal transverse mesocolon and the involvement of the mesocolon in acute pancreatitis (AP) as well as the relationship between the involvement of the mesocolon and the severity of AP. MATERIALS AND METHODS Forty patients without pancreatic disorders were retrospectively analyzed to observe the normal transverse mesocolon using MRI; 210 patients with...

Cross contamination of intramyocellular lipid (IMCL) signals through loss of bulk magnetic susceptibility (BMS) differences was detected in human muscles using proton magnetic resonance spectroscopic imaging ((1)H-MRSI) at 4 T by varying nominal voxel sizes on healthy subjects. In soleus muscle the IMCL content estimated in 1.00-ml-sized voxels was 15% and 30% higher than that in 0.25-ml voxels...

BACKGROUND Epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. Up to now, several diagnostic approaches have been processed to determine the epileptic focus. OBJECTIVES The aim of this study was to discover whether proton-MR-spectroscopic imaging (MRSI) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical e...