introduction: the estrogen receptors are potential candidates in prognosis and particularly in predicting hormone response therapy in breast cancer. the aim of this study was to measure erα gene expression due to study of the association between erα expression, age and menopause of iranian women with breast cancer. methods: 21 adenocarcinoma cases with grade 2 and 10 normal samples were screene...

background: mesenchymal stem cells (mscs) are multipotent cells, capable of differentiating into different cell lines.they can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. therefore, the exposure of these cells to endothelial growth factor (vegf) as well as hemodynamic biomechanical forces, which act on...

Background: Matrix MetalloProteinases (MMPs) degrade extracellular matrix components to provide normal remodeling and contribute to pathological tissue destruction and cell migration in endometriosis. It is accepted that MMPs are resistant to suppression by progesterone in endometriotic tissues. The physiological effects of progesterone are mediated by its two progesterone receptor (PR) isoform...

In article number 2100111, Song, Yang, and co-workers summarize recent advances in single-cell transcriptome sequencing multi-dimensional profiling. The investigation of mRNA enables the interrogation gene expression pattern, revealing cell-to-cell heterogeneity. measurement, including spatially temporally resolved analysis, multi-omics profiling allows a more comprehensive overview understandi...

Background Oocyte maturity includes nuclear and cytoplasmic maturity, both of which are important for embryo fertilization. The development of oocyte is not limited to the period of follicular growth, and starts from the embryonic period and continues throughout life. In this study, for the purpose of evaluating the effect of the FSH hormone on the expression of genes, GEO access codes for this...

The study was conducted to demonstrate expression profile of cold shock protein genes; cold inducible RNA binding protein (CIRP) and RNA binding motif protein 3 (RBM3) in goats (Capra hircus) during different seasons to check the gene expression in different thermal conditions. Blood samples were collected from healthy goats of tropical and temperate region during peak winter, moderate season a...

Background and Aims: Cadmium is an important environmental pollutant and a potent toxicant to organisms. However, the toxicity of Cadmium and its influences on stomach is still unclear. We examined the effects of intraperitoneal injection of Cadmium on mRNA expression of Bcl-2 and Bax genes in rat stomach. Materials and Methods: Twenty eight male Wistar rats weighing 200 to 250 g were randomly...

 Background: Chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. One of the main mechanisms of resistance to chemotherapy is the increased expression of MDR1 gene. The aim of this study was to explore the effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast of new...

breast cancer is the most common cancer in women worldwide. breast cancer in one third of all patients will go on to metastasis, which is the main cause of mortality in cancer cases. tumor cells detach from primary tumor and enter into the circulation as circulating tumor cells (ctcs) which can form metastatic lesions. in this study, the expression of ck-19 gene in blood samples of metastatic b...