OBJECTIVE The objective of our study was to investigate tumor conspicuity and the discrimination potential for tumor aggressiveness on diffusion-weighted magnetic resonance imaging (DW-MRI) with high b value at 3-T. MATERIALS AND METHODS The institutional review board approved this study and waived the requirement for informed consent. A total of 50 patients with prostate cancer (69 cancer fo...

G. K. Rohde, A. S. Barnett, P. J. Basser, S. Marenco, C. Pierpaoli National Institutes of Health, Bethesda, Maryland, United States SYNOPSIS: We present a method for removing artifacts related to patient motion and eddy-current induced image distortions in DW-MRI. The images are corrected for motion and distortion simultaneously using a well-established registration technique. Subject motion is...

BACKGROUND AND PURPOSE MRI may be used for noninvasive assessment of atherosclerotic lesions; however, MRI evaluation of plaque composition requires validation against an accepted reference standard, such as the American Heart Association (AHA) lesion grade, defined by histopathological examination. METHODS Forty-eight carotid endarterectomy specimen cross-sections had AHA lesion grade determ...

Introduction Chronic liver disease is a major public health problem worldwide (1). Early and accurate diagnosis of liver cirrhosis is crucial for prognostic assessment of the course of the disease. Liver biopsy, the standard for diagnosing liver fibrosis has many limitations, including invasiveness, sampling error, observer variability, and the use of categorical scoring system. Measurement of ...

Diffusion tensor imaging (DTI) constitutes the most used paradigm among the diffusion-weighted magnetic resonance imaging (DW-MRI) techniques due to its simplicity and application potential. Recently, real-time estimation in DW-MRI has deserved special attention, with several proposals aiming at the estimation of meaningful diffusion parameters during the repetition time of the acquisition sequ...

OBJECTIVE To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. METHODS Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reprod...

Introduction: Y-DOTATyr3octreotide (Y-DOTATOC) therapy targets tumour cells expressing somatostatin receptors and induces tumour apoptosis and necrosis. However, assessment of treatment response using conventional imaging criteria is unreliable because treatment may induce disease stabilization rather than disease regression, and disease can also be slow to regress despite clinical benefits [1]...