Despite an almost 80% overall survival rate in pediatric T-cell acute lymphoblastic leukemia (T-ALL), there is a subset of patients who are refractory to standard chemotherapy regimens and could benefit from novel treatment approaches. Over a 2-year period, we treated 5 pediatric patients with refractory T-ALL, aged 3 to 15 years, with high-dose cyclophosphamide (CY) at a dose of 2100 mg/m for ...

A significant part of scientific codes consist of sparse matrix computations. In this work we propose two new pseudoregular data distributions for sparse matrices. The Multiple Recursive Decomposition (MRD) partitions the data using the prime factors of the dimensions of a multiprocessor network with mesh topology. Furthermore, we introduce a new storage scheme, storage-by-row-of-blocks, that s...

In this paper, we describe how to exploit a machine-readable dictionary (MRD) and domain-specific text corpus in supporting the construction of domain on-tologies that specify taxonomic and non-taxonomic relationships among given domain concepts. A) In building taxonomic relationships (hierarchically structure) of domain concepts, some hierarchically structure can be extracted from a MRD with m...

Hedgehog (Hh) signaling pathway relates with a variety of tumors-related diseases. To examine whether Hh signaling has a role in acute myeloid leukemia (AML), twenty cases of AML patients were chosen, and the transcript levels of Hh and its receptors between untreated group and minimal residual disease (MRD)(-) group in patients with AML were compared. We also compared the transcript levels of ...

In this issue of Blood, Hovorkova and colleagues assessed minimal residual disease (MRD) sequentially in children with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph ALL) via BCR-ABL1 genomic polymerase chain reaction (PCR) and immunoglobulin gene (IG)/T-cell receptor gene (TCR) PCR in parallel. Results were concordant in most patients, but .20% of children with Ph ALL had MR...

The presence of acquired mutations within the JAK2, CALR, and MPL genes in the majority of patients with myeloproliferative neoplasms (MPN) affords the opportunity to utilise these mutations as markers of minimal residual disease (MRD). Reduction of the mutated allele burden has been reported in response to a number of therapeutic modalities including interferon, JAK inhibitors, and allogeneic ...

The prognostic value of minimal residual disease (MRD) measured by fusion-gene transcript (FGT) detection was investigated in 76 infants (aged ?1 year) with acute lymphoblastic leukaemia (ALL) lysine methyltransferase 2A (KMT2A) rearrangements. Either at the end induction or later time-points, FGT-MRD-positivity associated poor outcome. after first consolidation high-risk block detected 46·5% e...

Abstract Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and prognostic prior to allogeneic hematopoietic cell transplantation (alloHCT). We evaluated the role of clonal hematopoiesis–associated DNMT3A, TET2, ASXL1 (DTA) non-DTA mutations for MRD post-alloHCT refine marker selection. Of 154 AM...

Minimal residual disease (MRD) can be detected in many patients with leukemia who have achieved complete remission as defined by conventional pathology examination. The detection of MRD, be it by flow cytometry or by polymerase chain reaction assays, has now been found to be associated with subsequent relapses in most leukemia subtypes, either following chemotherapy or following hematopoietic s...

The goal of this project was to develop a piece of software to build a Lexical Knowledge Base (LKB) automatically by extracting information from a Machine Readable Dictionary (MRD). The extracted knowledge is represented using the Conceptual Graph (CG) formalism to give explicit information about noun and verb definitions. Sentences from the MRD are tagged, parsed and translated into conceptual...