OBJECTIVE To examine whether the combination of a low five minute Apgar score and symptoms of neonatal encephalopathy is associated with minor impairments at school age. DESIGN Population based cohort study. SETTING Norway. PARTICIPANTS All 727 children of the cohort were born between 1983 and 1987, had normal birth weights, no congenital malformations, and no major neurological abnormali...

Recent studies raise concern for combined exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg), two environmental contaminants that are found in fish and seafood. Past accidental poisonings in humans show that exposure to high levels of either contaminant is associated with motor impairments, including alterations in cerebellar functions such as balance and coordination. Epidem...

People with motor impairments often have difficulty entering text accurately when typing on a keyboard. These users also may have trouble correcting errors. We introduce TrueKeys, a system that automatically corrects typing errors as they occur. TrueKeys utilizes a word frequency list and a model of the user’s keyboard layout to identify typing errors and choose appropriate corrections. We eval...

Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain areas are still poorly understood. The role of nervous system integrity and axonal properties in prion pathology are still elusive. There is n...

Blind individuals show impairments for auditory spatial skills that require complex spatial representation of the environment. We suggest that this is partially due to the egocentric frame of reference used by blind individuals. Here we investigate the possibility of reducing the mentioned auditory spatial impairments with an audio-motor training. Our hypothesis is that the association between ...

Stress represents a critical influence on motor system function and has been shown to impair movement performance. We hypothesized that stress-induced motor impairments are due to brain-specific changes in miRNA and protein-encoding gene expression. Here we show a causal link between stress-induced motor impairment and associated genetic and epigenetic responses in relevant central motor areas ...