نتایج جستجو برای: motor dysfunction
تعداد نتایج: 309869 فیلتر نتایج به سال:
Pen-2 is a key regulator of the γ-secretase complex, which is involved in the production of the amyloid β (Aβ)-42 peptides, which ultimately lead to Alzheimer's disease (AD). While Pen-2 has been studied in vitro, Pen-2 function in vivo in the brains of transgenic (Tg) mice overexpressing human Pen-2 (hPen-2) protein has not been studied. This study aimed to determine whether Pen-2 overexpressi...
The early stages of Huntington's disease (HD) present with motor, cognitive, and emotional symptoms. Correspondingly, current models implicate dysfunction of the motor, associative, and limbic basal ganglia-thalamocortical circuits. Available data, however, indicate that in the early stages of the disease, striatal damage is mainly restricted to the associative striatum. Based on an open interc...
INTRODUCTION Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease (PD). The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with PD. METHODS Data from 96 patients with PD were obtained from the Parkinson's di...
Objectives. Morbidity and mortality in patients with cerebral palsy are related to motor function disability, as well as other contributing disorders. The aim of this study was to evaluate the contribution of epilepsy and other disorders in cerebral palsy patients using the Gross Motor Function Classification System (GMFCS), and to determine their relationship. Methods. This study was performed...
BACKGROUND Gray matter atrophy has been implicated in the development of secondary progressive multiple sclerosis (SPMS). Cortical function may be assessed by transcranial magnetic stimulation (TMS). Determining whether cortical dysfunction was a feature of SPMS could be of pathophysiological significance. OBJECTIVES Consequently, novel paired-pulse threshold tracking TMS techniques were used...
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