Temperature is an important determinant of malaria transmission. Recent work has shown that mosquito and parasite biology are influenced not only by average temperature, but also by the extent of the daily temperature variation. Here we examine how parasite development within the mosquito (Extrinsic Incubation Period) is expected to vary over time and space depending on the diurnal temperature ...

Blood-feeding mosquitoes are exposed to high levels of heme, the product of hemoglobin degradation. Heme is a pro-oxidant that influences a variety of cellular processes. We performed a global analysis of heme-regulated Aedes aegypti (yellow fever mosquito) transcriptional changes to better understand influence on mosquito physiology at the molecular level. We observed an iron- and reactive oxy...

1Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada 2Department of Biochemistry & Molecular Biology, 3Department of Clinical Neurosciences, and 4Department of Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta T2N 1N4, Canada 5Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands 6Department of Immunology, Tehran Univers...

Hadi Parsian1,2, Mohammad Nouri3, Ali Rahimipour4, Mohammad Hossein Somi3 and Durdi Qujeq1,2 1Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, 2Cellular and Molecular Biology Research Centre, Babol University of Medical Sciences, Babol, 3Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, 4Department of Clini...

BACKGROUND Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been predominantly one-sided investigations focusing on either of the partners involved. He...

Our ability to control diseases caused by parasitic nematodes is constrained by a limited portfolio of effective drugs and a paucity of robust tools to investigate parasitic nematode biology. RNA interference (RNAi) is a reverse-genetics tool with great potential to identify novel drug targets and interrogate parasite gene function, but present RNAi protocols for parasitic nematodes, which remo...

b a ckground: we aimed to extract the ingredients from leaves of gossypium hirsutum (bt cotton) using different solvents and evaluate for potential use to control different larval stages of mosquito species, aedes aegypti and anoph eles stephensi . m e t hods: qualitative and quantitative estimation of ingredients from go. hirsutum (bt) plant extract was carried out and their inhibitory action ...