In the title compound, C(25)H(36)N(2)O(2)S, the cyclo-hexane and morpholine rings adopt chair conformations. The cyclo-hexene and cyclo-hexane rings form a trans ring junction with the two methyl groups in axial positions. The N-H and C=O bonds in the urea group are anti to each other. The crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds.

In the title compound, C(14)H(20)N(2)O(3)·H(2)O, the geometry about the morpholine N atom implies sp(3) hybridization. In the crystal, symmetry-related mol-ecules are linked by inter-molecular N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds, forming infinite chains along the b axis. The chain structure is further stabilized by intra-molecular C-H⋯O inter-actions.

The title compound, (C(4)H(10)NO)(2)[CoCl(4)], is an ionic compound consisting of two protonated tetra-hydro-1,4-oxazine (morpholine) cations and a [CoCl(4)](2-) dianion. The Co(II) ion is in a tetra-hedral coordination geometry. The cations exhibit chair-shaped conformations. A three-dimensional supra-molecular architecture is formed through N-H⋯Cl and C-H⋯Cl hydrogen bonds between the dianion...

In the title compound, C(18)H(21)N(3)O(2)·H(2)O, the fused-ring system is approximately planar [maximum atomic deviation = 0.028 (3) Å]; the morpholine ring displays a chair conformation. The crystal packing is stabilized by classical inter-molecular O-H⋯O and O-H⋯N hydrogen bonds and weak C-H⋯O hydrogen bonds between the organic mol-ecules and the water mol-ecules.

In the title mononuclear nickel(II) complex, [Ni(C(13)H(15)I(2)N(2)O(2))(2)], the Ni(II) atom is four-coordinated in a tetra-hedral geometry by the imine N and phenolate O atoms of the two Schiff base ligands. The O and N atoms of the morpholine substituent in the ligand are not involved in coordination to the Ni atom.

In the title compound, C(18)H(20)N(2)O(3), the dihedral angle between the two aromatic rings is 33.66 (6)°. The morpholine ring adopts a chair conformation. The mol-ecular structure is stabilized by an intra-molecular O-H⋯N hydrogen bond. In the crystal, mol-ecules are linked via weak inter-molecular C-H⋯O and C-H⋯π inter-actions.

ICM0201 (1), a new inhibitor of murine osteoclastogenesis in culture was isolated from a fermentation broth of Cunninghamella sp. F-1490. The structure of ICM0201 was determined to be (3S,10aR)-3,4a-dihydroxy-2,3,4,4a-tetrahydro-2H-pyrano[3,2-b]benzo[e]morpholine-9-carboxylic acid by spectroscopic analyses and chemical studies. The structure of 1 is unique in that the tricycle ring system is co...